The PI3-Kinase Delta Inhibitor Idelalisib (GS-1101) Targets Integrin-Mediated Adhesion of Chronic Lymphocytic Leukemia (CLL) Cell to Endothelial and Marrow Stromal Cells

Stefania Fiorcari; Wells S. Brown; Bradley W. McIntyre; Zeev Estrov; Rossana Maffei; Susan O’Brien; Mariela Sivina; Julia Hoellenriegel; William G. Wierda; Michael J. Keating; Wei Ding; Neil E. Kay; Brian J. Lannutti; Roberto Marasca; Jan A. Burger

doi:10.1371/journal.pone.0083830

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Open Access

Peer-reviewed

Research Article

The PI3-Kinase Delta Inhibitor Idelalisib (GS-1101) Targets Integrin-Mediated Adhesion of Chronic Lymphocytic Leukemia (CLL) Cell to Endothelial and Marrow Stromal Cells

Stefania Fiorcari,

Affiliations Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy
⨯
Wells S. Brown,

Affiliation Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Bradley W. McIntyre,

Affiliation Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Zeev Estrov,

Affiliation Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Rossana Maffei,

Affiliation Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy
⨯
Susan O’Brien,

Affiliation Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Mariela Sivina,

Affiliation Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Julia Hoellenriegel,

Affiliation Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
William G. Wierda,

Affiliation Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Michael J. Keating,

Affiliation Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Wei Ding,

Affiliation Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Neil E. Kay,

Affiliation Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Brian J. Lannutti,

Affiliation Gilead Sciences, Inc. Seattle, Washington, United States of America
⨯
Roberto Marasca,

Affiliation Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy
⨯
Jan A. Burger

* E-mail: jaburger@mdanderson.org

Affiliation Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯

The PI3-Kinase Delta Inhibitor Idelalisib (GS-1101) Targets Integrin-Mediated Adhesion of Chronic Lymphocytic Leukemia (CLL) Cell to Endothelial and Marrow Stromal Cells

Stefania Fiorcari,
Wells S. Brown,
Bradley W. McIntyre,
Zeev Estrov,
Rossana Maffei,
Susan O’Brien,
Mariela Sivina,
Julia Hoellenriegel,
William G. Wierda,
Michael J. Keating

Published: December 23, 2013
https://doi.org/10.1371/journal.pone.0083830

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