ERK2-Mediated Phosphorylation of Transcriptional Coactivator Binding Protein PIMT/NCoA6IP at Ser298 Augments Hepatic Gluconeogenesis

Bandish Kapadia; Navin Viswakarma; Kishore V. L. Parsa; Vasundhara Kain; Soma Behera; Sashidhara Kaimal Suraj; Phanithi Prakash Babu; Anand Kar; Sunanda Panda; Yi-jun Zhu; Yuzhi Jia; Bayar Thimmapaya; Janardan K. Reddy; Parimal Misra

doi:10.1371/journal.pone.0083787

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Open Access

Peer-reviewed

Research Article

ERK2-Mediated Phosphorylation of Transcriptional Coactivator Binding Protein PIMT/NCoA6IP at Ser²⁹⁸ Augments Hepatic Gluconeogenesis

Bandish Kapadia ,

Contributed equally to this work with: Bandish Kapadia, Navin Viswakarma

Affiliation Department of Biology, Dr Reddy’s Institute of Life Sciences, An Associate Institute of University of Hyderabad, Hyderabad, Andhra Pradesh, India
⨯
Navin Viswakarma ,

Contributed equally to this work with: Bandish Kapadia, Navin Viswakarma

Current address: Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago, Maywood, Illinois, United States of America

Affiliation Department of Biology, Dr Reddy’s Institute of Life Sciences, An Associate Institute of University of Hyderabad, Hyderabad, Andhra Pradesh, India
⨯
Kishore V. L. Parsa,

Affiliation Department of Biology, Dr Reddy’s Institute of Life Sciences, An Associate Institute of University of Hyderabad, Hyderabad, Andhra Pradesh, India
⨯
Vasundhara Kain,

Affiliation Department of Biology, Dr Reddy’s Institute of Life Sciences, An Associate Institute of University of Hyderabad, Hyderabad, Andhra Pradesh, India
⨯
Soma Behera,

Affiliation Department of Biology, Dr Reddy’s Institute of Life Sciences, An Associate Institute of University of Hyderabad, Hyderabad, Andhra Pradesh, India
⨯
Sashidhara Kaimal Suraj,

Affiliation Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad, Andhra Pradesh, India
⨯
Phanithi Prakash Babu,

Affiliation Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad, Andhra Pradesh, India
⨯
Anand Kar,

Affiliation Department of Life Sciences, Devi Ahilya University, Indore, Madhya Pradesh, India
⨯
Sunanda Panda,

Affiliation Department of Life Sciences, Devi Ahilya University, Indore, Madhya Pradesh, India
⨯
Yi-jun Zhu,

Affiliation Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Yuzhi Jia,

Affiliation Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Bayar Thimmapaya,

Affiliation Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Janardan K. Reddy ,

* E-mail: parimalm@drils.org (PM); jkreddy@northwestern.edu (JKR)

Affiliation Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Parimal Misra

* E-mail: parimalm@drils.org (PM); jkreddy@northwestern.edu (JKR)

Affiliation Department of Biology, Dr Reddy’s Institute of Life Sciences, An Associate Institute of University of Hyderabad, Hyderabad, Andhra Pradesh, India
⨯

ERK2-Mediated Phosphorylation of Transcriptional Coactivator Binding Protein PIMT/NCoA6IP at Ser²⁹⁸ Augments Hepatic Gluconeogenesis

Bandish Kapadia,
Navin Viswakarma,
Kishore V. L. Parsa,
Vasundhara Kain,
Soma Behera,
Sashidhara Kaimal Suraj,
Phanithi Prakash Babu,
Anand Kar,
Sunanda Panda,
Yi-jun Zhu

Published: December 17, 2013
https://doi.org/10.1371/journal.pone.0083787

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Phosphorylation
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Glucose
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Hepatocytes
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Hyperexpression techniques
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Transfection
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Transcriptional control
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Thyroid hormones
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Gene expression
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