Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations

Hong Wu; Hong Zeng; Aiping Dong; Fengling Li; Hao He; Guillermo Senisterra; Alma Seitova; Shili Duan; Peter J. Brown; Masoud Vedadi; Cheryl H. Arrowsmith; Matthieu Schapira

doi:10.1371/journal.pone.0083737

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Peer-reviewed

Research Article

Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations

Hong Wu,

Affiliation Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada
⨯
Hong Zeng,

Affiliation Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada
⨯
Aiping Dong,

Affiliation Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada
⨯
Fengling Li,

Affiliation Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada
⨯
Hao He,

Affiliation Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada
⨯
Guillermo Senisterra,

Affiliation Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada
⨯
Alma Seitova,

Affiliation Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada
⨯
Shili Duan,

Affiliation Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
⨯
Peter J. Brown,

Affiliation Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada
⨯
Masoud Vedadi,

Affiliations Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada, Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
⨯
Cheryl H. Arrowsmith ,

* E-mail: carrow@uhnresearch.ca (CHA); matthieu.schapira@utoronto.ca (MS)

Affiliations Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada, Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
⨯
Matthieu Schapira

* E-mail: carrow@uhnresearch.ca (CHA); matthieu.schapira@utoronto.ca (MS)

Affiliations Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada, Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
⨯

Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations

Hong Wu,
Hong Zeng,
Aiping Dong,
Fengling Li,
Hao He,
Guillermo Senisterra,
Alma Seitova,
Shili Duan,
Peter J. Brown,
Masoud Vedadi

Published: December 19, 2013
https://doi.org/10.1371/journal.pone.0083737

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