Knockdown of Hsc70-5/mortalin Induces Loss of Synaptic Mitochondria in a Drosophila Parkinson’s Disease Model

Jun-yi Zhu; Natalia Vereshchagina; Vrinda Sreekumar; Lena F. Burbulla; Ana C. Costa; Katharina J. Daub; Dirk Woitalla; L. Miguel Martins; Rejko Krüger; Tobias M. Rasse

doi:10.1371/journal.pone.0083714

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Peer-reviewed

Research Article

Knockdown of Hsc70-5/mortalin Induces Loss of Synaptic Mitochondria in a Drosophila Parkinson’s Disease Model

Jun-yi Zhu,

Affiliations Junior Research Group Synaptic Plasticity, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany, Graduate School of Cellular & Molecular Neuroscience, University of Tübingen, Tübingen, Germany
⨯
Natalia Vereshchagina,

Affiliation Junior Research Group Synaptic Plasticity, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
⨯
Vrinda Sreekumar,

Affiliations Junior Research Group Synaptic Plasticity, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany, Graduate School of Cellular & Molecular Neuroscience, University of Tübingen, Tübingen, Germany, German Center for Neurodegenerative Diseases, Tübingen, Germany
⨯
Lena F. Burbulla,

Affiliations German Center for Neurodegenerative Diseases, Tübingen, Germany, Department of Neurodegenerative Diseases and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
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Ana C. Costa,

Affiliation Cell Death Regulation Laboratory, MRC Toxicology Unit, Leicester, United Kingdom
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Katharina J. Daub,

Affiliation Junior Research Group Synaptic Plasticity, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
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Dirk Woitalla,

Affiliation Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany
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L. Miguel Martins,

Affiliation Cell Death Regulation Laboratory, MRC Toxicology Unit, Leicester, United Kingdom
⨯
Rejko Krüger ,

* E-mail: tobias.rasse@gmail.de (TMR); rejko.krueger@uni-tuebingen.de (RK)

Affiliations German Center for Neurodegenerative Diseases, Tübingen, Germany, Department of Neurodegenerative Diseases and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany, Werner Reichardt Centre for Integrative Neuroscience, University of Tübingen, Tübingen, Germany
⨯
Tobias M. Rasse

* E-mail: tobias.rasse@gmail.de (TMR); rejko.krueger@uni-tuebingen.de (RK)

Affiliation Junior Research Group Synaptic Plasticity, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
⨯

Knockdown of Hsc70-5/mortalin Induces Loss of Synaptic Mitochondria in a Drosophila Parkinson’s Disease Model

Jun-yi Zhu,
Natalia Vereshchagina,
Vrinda Sreekumar,
Lena F. Burbulla,
Ana C. Costa,
Katharina J. Daub,
Dirk Woitalla,
L. Miguel Martins,
Rejko Krüger,
Tobias M. Rasse

Published: December 30, 2013
https://doi.org/10.1371/journal.pone.0083714

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Mitochondria
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Larvae
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Drosophila melanogaster
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Parkinson disease
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Biological locomotion
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