Integrin α6β4 Identifies Human Distal Lung Epithelial Progenitor Cells with Potential as a Cell-Based Therapy for Cystic Fibrosis Lung Disease

Xiaopeng Li; Nathan Rossen; Patrick L. Sinn; Andrew L. Hornick; Benjamin R. Steines; Philip H. Karp; Sarah E. Ernst; Ryan J. Adam; Thomas O. Moninger; Dana N. Levasseur; Joseph Zabner

doi:10.1371/journal.pone.0083624

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Peer-reviewed

Research Article

Integrin α6β4 Identifies Human Distal Lung Epithelial Progenitor Cells with Potential as a Cell-Based Therapy for Cystic Fibrosis Lung Disease

Xiaopeng Li ,

* E-mail: Xiaopeng-Li@uiowa.edu (XL); Joseph-Zabner@uiowa.edu (JZ)

Affiliation Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Nathan Rossen,

Affiliation Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
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Patrick L. Sinn,

Affiliation Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
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Andrew L. Hornick,

Affiliation Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
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Benjamin R. Steines,

Affiliation Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
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Philip H. Karp,

Affiliation Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
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Sarah E. Ernst,

Affiliation Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Ryan J. Adam,

Affiliation Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Thomas O. Moninger,

Affiliation Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Dana N. Levasseur,

Affiliation Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Joseph Zabner

* E-mail: Xiaopeng-Li@uiowa.edu (XL); Joseph-Zabner@uiowa.edu (JZ)

Affiliation Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯

Integrin α6β4 Identifies Human Distal Lung Epithelial Progenitor Cells with Potential as a Cell-Based Therapy for Cystic Fibrosis Lung Disease

Xiaopeng Li,
Nathan Rossen,
Patrick L. Sinn,
Andrew L. Hornick,
Benjamin R. Steines,
Philip H. Karp,
Sarah E. Ernst,
Ryan J. Adam,
Thomas O. Moninger,
Dana N. Levasseur

Published: December 12, 2013
https://doi.org/10.1371/journal.pone.0083624

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Epithelial cells
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Stem cells
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Cell differentiation
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Lung development
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Cystic fibrosis
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Integrins
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Pulmonary imaging
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