Effects of Troponin T Cardiomyopathy Mutations on the Calcium Sensitivity of the Regulated Thin Filament and the Actomyosin Cross-Bridge Kinetics of Human β-Cardiac Myosin

• Ruth F. Sommese ,

  Contributed equally to this work with: Ruth F. Sommese, Suman Nag

  Affiliation Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America

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• Suman Nag ,

  Contributed equally to this work with: Ruth F. Sommese, Suman Nag

  Affiliation Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America

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• Shirley Sutton,

  Affiliation Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America

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• Susan M. Miller,

  Affiliation Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

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• James A. Spudich ,

  * E-mail: kruppel@stanford.edu (KR); jspudich@stanford.edu (JS)

  Affiliation Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America

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• Kathleen M. Ruppel

  * E-mail: kruppel@stanford.edu (KR); jspudich@stanford.edu (JS)

  Affiliations Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America, Department of Pediatrics (Cardiology), Stanford University School of Medicine, Stanford, California, United States of America

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