Targeted Expression of Suicide Gene by Tissue-Specific Promoter and MicroRNA Regulation for Cancer Gene Therapy

Ravikanth Danda; Gopinath Krishnan; Kalaivani Ganapathy; Uma Maheswari Krishnan; Khetan Vikas; Sailaja Elchuri; Nivedita Chatterjee; Subramanian Krishnakumar

doi:10.1371/journal.pone.0083398

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Open Access

Peer-reviewed

Research Article

Targeted Expression of Suicide Gene by Tissue-Specific Promoter and MicroRNA Regulation for Cancer Gene Therapy

Ravikanth Danda ,

Contributed equally to this work with: Ravikanth Danda, Gopinath Krishnan

Affiliations Department of Ocular Pathology, Vision Research Foundation, Sankara Nethralaya, Chennai, India, Centre for Nanotechnology and Advanced Biomaterials, Shanmugha Arts, Science, Technology and Research Academy University, Tanjore, India
⨯
Gopinath Krishnan ,

Contributed equally to this work with: Ravikanth Danda, Gopinath Krishnan

Affiliations Department of Ocular Pathology, Vision Research Foundation, Sankara Nethralaya, Chennai, India, Centre for Nanotechnology and Advanced Biomaterials, Shanmugha Arts, Science, Technology and Research Academy University, Tanjore, India
⨯
Kalaivani Ganapathy,

Affiliation Department of Ocular Pathology, Vision Research Foundation, Sankara Nethralaya, Chennai, India
⨯
Uma Maheswari Krishnan,

Affiliation Centre for Nanotechnology and Advanced Biomaterials, Shanmugha Arts, Science, Technology and Research Academy University, Tanjore, India
⨯
Khetan Vikas,

Affiliation Departments of Ocular Oncology and Vitreoretina, Medical Research Foundation, Sankara Nethralaya, Chennai, India
⨯
Sailaja Elchuri,

Affiliation Department of Ocular Pathology, Vision Research Foundation, Sankara Nethralaya, Chennai, India
⨯
Nivedita Chatterjee,

Affiliation Department of Ocular Pathology, Vision Research Foundation, Sankara Nethralaya, Chennai, India
⨯
Subramanian Krishnakumar

* E-mail: drkk@snmail.org

Affiliation Department of Ocular Pathology, Vision Research Foundation, Sankara Nethralaya, Chennai, India
⨯

Targeted Expression of Suicide Gene by Tissue-Specific Promoter and MicroRNA Regulation for Cancer Gene Therapy

Ravikanth Danda,
Gopinath Krishnan,
Kalaivani Ganapathy,
Uma Maheswari Krishnan,
Khetan Vikas,
Sailaja Elchuri,
Nivedita Chatterjee,
Subramanian Krishnakumar

Published: December 31, 2013
https://doi.org/10.1371/journal.pone.0083398

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MicroRNAs
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Transfection
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Gene expression
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Luciferase
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Breast cancer
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Thyroid carcinoma
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Apoptosis
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Cancer treatment
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