Quiescent Hepatic Stellate Cells Functionally Contribute to the Hepatic Innate Immune Response via TLR3

Caroline L. Wilson; Jelena Mann; Meagan Walsh; Maria J. Perrugoria; Fiona Oakley; Matthew C. Wright; Chiara Brignole; Daniela Di Paolo; Patrizia Perri; Mirco Ponzoni; Michael Karin; Derek A. Mann

doi:10.1371/journal.pone.0083391

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Open Access

Peer-reviewed

Research Article

Quiescent Hepatic Stellate Cells Functionally Contribute to the Hepatic Innate Immune Response via TLR3

Caroline L. Wilson ,

Contributed equally to this work with: Caroline L. Wilson, Jelena Mann

Affiliation Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Jelena Mann ,

Contributed equally to this work with: Caroline L. Wilson, Jelena Mann

Affiliation Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Meagan Walsh,

Affiliation Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Maria J. Perrugoria,

Affiliation Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Fiona Oakley,

Affiliation Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Matthew C. Wright,

Affiliation Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Chiara Brignole,

Affiliation Experimental Therapy Unit, Laboratory of Oncology, Istituto Giannina Gaslini, Genoa, Italy
⨯
Daniela Di Paolo,

Affiliation Experimental Therapy Unit, Laboratory of Oncology, Istituto Giannina Gaslini, Genoa, Italy
⨯
Patrizia Perri,

Affiliation Experimental Therapy Unit, Laboratory of Oncology, Istituto Giannina Gaslini, Genoa, Italy
⨯
Mirco Ponzoni,

Affiliation Experimental Therapy Unit, Laboratory of Oncology, Istituto Giannina Gaslini, Genoa, Italy
⨯
Michael Karin,

Affiliation Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Pathology, School of Medicine, University of California San Diego, La Jolla, California, United States of America
⨯
Derek A. Mann

* E-mail: Derek.Mann@ncl.ac.uk

Affiliation Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯

Quiescent Hepatic Stellate Cells Functionally Contribute to the Hepatic Innate Immune Response via TLR3

Caroline L. Wilson,
Jelena Mann,
Meagan Walsh,
Maria J. Perrugoria,
Fiona Oakley,
Matthew C. Wright,
Chiara Brignole,
Daniela Di Paolo,
Patrizia Perri,
Mirco Ponzoni

Published: January 8, 2014
https://doi.org/10.1371/journal.pone.0083391

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09 Apr 2014
10:12 GMT
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Faculty 1000 recommended Posted by Derek_Mann on 09 Apr 2014 at 10:12 GMT

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Toll-like receptors
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Interferons
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Immune response
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Genetic interference
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Macrophages
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Immune receptor signaling
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Messenger RNA
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