Discovery and Preclinical Characterization of Novel Small Molecule TRK and ROS1 Tyrosine Kinase Inhibitors for the Treatment of Cancer and Inflammation

Ramesh Narayanan; Muralimohan Yepuru; Christopher C. Coss; Zhongzhi Wu; Matthew N. Bauler; Christina M. Barrett; Michael L. Mohler; Yun Wang; Juhyun Kim; Linda M. Snyder; Yali He; Nelson Levy; Duane D. Miller; James T. Dalton

doi:10.1371/journal.pone.0083380

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Open Access

Peer-reviewed

Research Article

Discovery and Preclinical Characterization of Novel Small Molecule TRK and ROS1 Tyrosine Kinase Inhibitors for the Treatment of Cancer and Inflammation

Ramesh Narayanan ,

* E-mail: rnarayanan@gtxinc.com (RN); jdalton@gtxinc.com (JTD)

¶RN and MY share first authorship on this work.

Affiliation Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America
⨯
Muralimohan Yepuru ,

¶RN and MY share first authorship on this work.

Affiliation Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America
⨯
Christopher C. Coss,

Affiliation Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America
⨯
Zhongzhi Wu,

Affiliation Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America
⨯
Matthew N. Bauler,

Affiliation Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America
⨯
Christina M. Barrett,

Affiliation Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America
⨯
Michael L. Mohler,

Affiliation Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America
⨯
Yun Wang,

Affiliation Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America
⨯
Juhyun Kim,

Affiliation Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America
⨯
Linda M. Snyder,

Affiliation Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America
⨯
Yali He,

Affiliation Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America
⨯
Nelson Levy,

Affiliation Chembridge Research Laboratory, San Diego, California, United States of America
⨯
Duane D. Miller,

Affiliation Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America
⨯
James T. Dalton

* E-mail: rnarayanan@gtxinc.com (RN); jdalton@gtxinc.com (JTD)

Affiliation Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America
⨯

Discovery and Preclinical Characterization of Novel Small Molecule TRK and ROS1 Tyrosine Kinase Inhibitors for the Treatment of Cancer and Inflammation

Ramesh Narayanan,
Muralimohan Yepuru,
Christopher C. Coss,
Zhongzhi Wu,
Matthew N. Bauler,
Christina M. Barrett,
Michael L. Mohler,
Yun Wang,
Juhyun Kim,
Linda M. Snyder

Published: December 26, 2013
https://doi.org/10.1371/journal.pone.0083380

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