Notch γ-Secretase Inhibitor Dibenzazepine Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm in ApoE Knockout Mice by Multiple Mechanisms

Yue-Hong Zheng; Fang-Da Li; Cui Tian; Hua-Liang Ren; Jie Du; Hui-Hua Li

doi:10.1371/journal.pone.0083310

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Peer-reviewed

Research Article

Notch γ-Secretase Inhibitor Dibenzazepine Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm in ApoE Knockout Mice by Multiple Mechanisms

Yue-Hong Zheng ,

* E-mail: hhli1995@yahoo.com (HHL); yuehongzheng@yahoo.com (YHZ)

Affiliation Department of Vascular Surgery, Peking Union Medical Hospital, Beijing, China
⨯
Fang-Da Li,

Affiliation Department of Vascular Surgery, Peking Union Medical Hospital, Beijing, China
⨯
Cui Tian,

Affiliation Department of Physiology and Physiopathology, Beijing AnZhen Hospital the Key Laboratory of Remodeling-Related Cardiovascular Diseases, Beijing Key Laboratory of Cardiovascular Diseases Related to Metabolic Disturbance, School of Basic Medical Sciences, Capital Medical University, Beijing, China; Beijing Institute of Heart, Lung and Blood vessel Diseases, Beijing, China
⨯
Hua-Liang Ren,

Affiliation Department of Vascular Surgery, Peking Union Medical Hospital, Beijing, China
⨯
Jie Du,

Affiliation Department of Physiology and Physiopathology, Beijing AnZhen Hospital the Key Laboratory of Remodeling-Related Cardiovascular Diseases, Beijing Key Laboratory of Cardiovascular Diseases Related to Metabolic Disturbance, School of Basic Medical Sciences, Capital Medical University, Beijing, China; Beijing Institute of Heart, Lung and Blood vessel Diseases, Beijing, China
⨯
Hui-Hua Li

* E-mail: hhli1995@yahoo.com (HHL); yuehongzheng@yahoo.com (YHZ)

Affiliation Department of Physiology and Physiopathology, Beijing AnZhen Hospital the Key Laboratory of Remodeling-Related Cardiovascular Diseases, Beijing Key Laboratory of Cardiovascular Diseases Related to Metabolic Disturbance, School of Basic Medical Sciences, Capital Medical University, Beijing, China; Beijing Institute of Heart, Lung and Blood vessel Diseases, Beijing, China
⨯

Notch γ-Secretase Inhibitor Dibenzazepine Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm in ApoE Knockout Mice by Multiple Mechanisms

Yue-Hong Zheng,
Fang-Da Li,
Cui Tian,
Hua-Liang Ren,
Jie Du,
Hui-Hua Li

Published: December 16, 2013
https://doi.org/10.1371/journal.pone.0083310

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Aorta
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