Proof of the Concept to Use a Malignant B Cell Line Drug Screen Strategy for Identification and Weight of Melphalan Resistance Genes in Multiple Myeloma

Martin Bøgsted; Anders E. Bilgrau; Christopher P. Wardell; Uta Bertsch; Alexander Schmitz; Julie S. Bødker; Malene K. Kjeldsen; Hartmut Goldschmidt; Gareth J. Morgan; Karen Dybkaer; Hans E. Johnsen

doi:10.1371/journal.pone.0083252

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Open Access

Peer-reviewed

Research Article

Proof of the Concept to Use a Malignant B Cell Line Drug Screen Strategy for Identification and Weight of Melphalan Resistance Genes in Multiple Myeloma

Martin Bøgsted,

Affiliations Department of Haematology, Aalborg Hospital Science and Innovation Center (AHSIC), Aalborg University Hospital, Aalborg, Denmark, Department of Mathematical Sciences, Aalborg University, Aalborg, Denmark
⨯
Anders E. Bilgrau,

Affiliations Department of Haematology, Aalborg Hospital Science and Innovation Center (AHSIC), Aalborg University Hospital, Aalborg, Denmark, Department of Mathematical Sciences, Aalborg University, Aalborg, Denmark
⨯
Christopher P. Wardell,

Affiliation Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom
⨯
Uta Bertsch,

Affiliation Department of Internal Medicine V and National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany
⨯
Alexander Schmitz,

Affiliation Department of Haematology, Aalborg Hospital Science and Innovation Center (AHSIC), Aalborg University Hospital, Aalborg, Denmark
⨯
Julie S. Bødker,

Affiliation Department of Haematology, Aalborg Hospital Science and Innovation Center (AHSIC), Aalborg University Hospital, Aalborg, Denmark
⨯
Malene K. Kjeldsen,

Affiliation Department of Haematology, Aalborg Hospital Science and Innovation Center (AHSIC), Aalborg University Hospital, Aalborg, Denmark
⨯
Hartmut Goldschmidt,

Affiliation Department of Internal Medicine V and National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany
⨯
Gareth J. Morgan,

Affiliation Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom
⨯
Karen Dybkaer,

Affiliation Department of Haematology, Aalborg Hospital Science and Innovation Center (AHSIC), Aalborg University Hospital, Aalborg, Denmark
⨯
Hans E. Johnsen

* E-mail: haej@rn.dk

Affiliation Department of Haematology, Aalborg Hospital Science and Innovation Center (AHSIC), Aalborg University Hospital, Aalborg, Denmark
⨯

Proof of the Concept to Use a Malignant B Cell Line Drug Screen Strategy for Identification and Weight of Melphalan Resistance Genes in Multiple Myeloma

Martin Bøgsted,
Anders E. Bilgrau,
Christopher P. Wardell,
Uta Bertsch,
Alexander Schmitz,
Julie S. Bødker,
Malene K. Kjeldsen,
Hartmut Goldschmidt,
Gareth J. Morgan,
Karen Dybkaer

Published: December 20, 2013
https://doi.org/10.1371/journal.pone.0083252

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Multiple myeloma
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Gene expression
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B cells
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Cancers and neoplasms
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Drug screening
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Hematologic cancers and related disorders
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