RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist

Kevin G. McLure; Emily M. Gesner; Laura Tsujikawa; Olesya A. Kharenko; Sarah Attwell; Eric Campeau; Sylwia Wasiak; Adam Stein; Andre White; Eric Fontano; Robert K. Suto; Norman C. W. Wong; Gregory S. Wagner; Henrik C. Hansen; Peter R. Young

doi:10.1371/journal.pone.0083190

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Open Access

Peer-reviewed

Research Article

RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist

Kevin G. McLure ,

* E-mail: kevin@resverlogix.com

Affiliation Resverlogix Corp., Calgary, Alberta, Canada, or San Francisco, California, United States of America
⨯
Emily M. Gesner,

Affiliation Resverlogix Corp., Calgary, Alberta, Canada, or San Francisco, California, United States of America
⨯
Laura Tsujikawa,

Affiliation Resverlogix Corp., Calgary, Alberta, Canada, or San Francisco, California, United States of America
⨯
Olesya A. Kharenko,

Affiliation Resverlogix Corp., Calgary, Alberta, Canada, or San Francisco, California, United States of America
⨯
Sarah Attwell,

Affiliation Resverlogix Corp., Calgary, Alberta, Canada, or San Francisco, California, United States of America
⨯
Eric Campeau,

Affiliation Resverlogix Corp., Calgary, Alberta, Canada, or San Francisco, California, United States of America
⨯
Sylwia Wasiak,

Affiliation Resverlogix Corp., Calgary, Alberta, Canada, or San Francisco, California, United States of America
⨯
Adam Stein,

Current address: Cayman Chemical, Ann Arbor, Michigan, United States of America

Affiliation Xtal BioStructures Inc., Natick, Maryland, United States of America
⨯
Andre White,

Affiliation Xtal BioStructures Inc., Natick, Maryland, United States of America
⨯
Eric Fontano,

Affiliation Xtal BioStructures Inc., Natick, Maryland, United States of America
⨯
Robert K. Suto,

Affiliation Xtal BioStructures Inc., Natick, Maryland, United States of America
⨯
Norman C. W. Wong,

Affiliation Resverlogix Corp., Calgary, Alberta, Canada, or San Francisco, California, United States of America
⨯
Gregory S. Wagner,

Affiliation Resverlogix Corp., Calgary, Alberta, Canada, or San Francisco, California, United States of America
⨯
Henrik C. Hansen,

Affiliation Resverlogix Corp., Calgary, Alberta, Canada, or San Francisco, California, United States of America
⨯
Peter R. Young

Affiliation Resverlogix Corp., Calgary, Alberta, Canada, or San Francisco, California, United States of America
⨯

RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist

Kevin G. McLure,
Emily M. Gesner,
Laura Tsujikawa,
Olesya A. Kharenko,
Sarah Attwell,
Eric Campeau,
Sylwia Wasiak,
Adam Stein,
Andre White,
Eric Fontano

Published: December 31, 2013
https://doi.org/10.1371/journal.pone.0083190

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