Evaluation of the Antitumor Effects of BPR1J-340, a Potent and Selective FLT3 Inhibitor, Alone or in Combination with an HDAC Inhibitor, Vorinostat, in AML Cancer

Wen-Hsing Lin; Teng-Kuang Yeh; Weir-Torn Jiaang; Kuei-Jung Yen; Chun-Hwa Chen; Chin-Ting Huang; Shih-Chieh Yen; Shu-Yi Hsieh; Ling-Hui Chou; Ching-Ping Chen; Chun-Hsien Chiu; Li-Chun Kao; Yu-Sheng Chao; Chiung-Tong Chen; John T.-A. Hsu

doi:10.1371/journal.pone.0083160

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Open Access

Peer-reviewed

Research Article

Evaluation of the Antitumor Effects of BPR1J-340, a Potent and Selective FLT3 Inhibitor, Alone or in Combination with an HDAC Inhibitor, Vorinostat, in AML Cancer

Wen-Hsing Lin ,

Contributed equally to this work with: Wen-Hsing Lin, Teng-Kuang Yeh, Weir-Torn Jiaang

Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan
⨯
Teng-Kuang Yeh ,

Contributed equally to this work with: Wen-Hsing Lin, Teng-Kuang Yeh, Weir-Torn Jiaang

Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan
⨯
Weir-Torn Jiaang ,

Contributed equally to this work with: Wen-Hsing Lin, Teng-Kuang Yeh, Weir-Torn Jiaang

Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan
⨯
Kuei-Jung Yen,

Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan
⨯
Chun-Hwa Chen,

Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan
⨯
Chin-Ting Huang,

Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan
⨯
Shih-Chieh Yen,

Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan
⨯
Shu-Yi Hsieh,

Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan
⨯
Ling-Hui Chou,

Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan
⨯
Ching-Ping Chen,

Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan
⨯
Chun-Hsien Chiu,

Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan
⨯
Li-Chun Kao,

Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan
⨯
Yu-Sheng Chao,

Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan
⨯
Chiung-Tong Chen ,

* E-mail: ctchen@nhri.org.tw (CTC); tsuanhsu@nhri.org.tw (JT-AH)

Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan
⨯
John T.-A. Hsu

* E-mail: ctchen@nhri.org.tw (CTC); tsuanhsu@nhri.org.tw (JT-AH)

Affiliations Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan, Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan
⨯

Evaluation of the Antitumor Effects of BPR1J-340, a Potent and Selective FLT3 Inhibitor, Alone or in Combination with an HDAC Inhibitor, Vorinostat, in AML Cancer

Wen-Hsing Lin,
Teng-Kuang Yeh,
Weir-Torn Jiaang,
Kuei-Jung Yen,
Chun-Hwa Chen,
Chin-Ting Huang,
Shih-Chieh Yen,
Shu-Yi Hsieh,
Ling-Hui Chou,
Ching-Ping Chen

Published: January 8, 2014
https://doi.org/10.1371/journal.pone.0083160

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