Sequential Dosing in Chemosensitization: Targeting the PI3K/Akt/mTOR Pathway in Neuroblastoma

Mike-Andrew Westhoff; Najmeh Faham; Daniela Marx; Lisa Nonnenmacher; Claudia Jennewein; Stefanie Enzenmüller; Patrick Gonzalez; Simone Fulda; Klaus-Michael Debatin

doi:10.1371/journal.pone.0083128

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Open Access

Peer-reviewed

Research Article

Sequential Dosing in Chemosensitization: Targeting the PI3K/Akt/mTOR Pathway in Neuroblastoma

Mike-Andrew Westhoff,

Affiliation Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
⨯
Najmeh Faham ,

Contributed equally to this work with: Najmeh Faham, Daniela Marx

Affiliation Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
⨯
Daniela Marx ,

Contributed equally to this work with: Najmeh Faham, Daniela Marx

Affiliation Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
⨯
Lisa Nonnenmacher,

Affiliation Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
⨯
Claudia Jennewein,

Affiliation Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
⨯
Stefanie Enzenmüller,

Affiliation Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
⨯
Patrick Gonzalez,

Affiliation Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
⨯
Simone Fulda ,

* E-mail: simone.fulda@kgu.de (SF); klaus-michael.debatin@uniklinik-ulm.de (KMD)

Current address: Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Germany

¶These authors share senior authorship.

Affiliation Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
⨯
Klaus-Michael Debatin

* E-mail: simone.fulda@kgu.de (SF); klaus-michael.debatin@uniklinik-ulm.de (KMD)

¶These authors share senior authorship.

Affiliation Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
⨯

Sequential Dosing in Chemosensitization: Targeting the PI3K/Akt/mTOR Pathway in Neuroblastoma

Mike-Andrew Westhoff,
Najmeh Faham,
Daniela Marx,
Lisa Nonnenmacher,
Claudia Jennewein,
Stefanie Enzenmüller,
Patrick Gonzalez,
Simone Fulda,
Klaus-Michael Debatin

Published: December 31, 2013
https://doi.org/10.1371/journal.pone.0083128

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