MicroRNA-10b Promotes Nucleus Pulposus Cell Proliferation through RhoC-Akt Pathway by Targeting HOXD10 in Intervetebral Disc Degeneration

Xin Yu; Zheng Li; Jianxiong Shen; William K. K. Wu; Jinqian Liang; Xisheng Weng; Guixing Qiu

doi:10.1371/journal.pone.0083080

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Peer-reviewed

Research Article

MicroRNA-10b Promotes Nucleus Pulposus Cell Proliferation through RhoC-Akt Pathway by Targeting HOXD10 in Intervetebral Disc Degeneration

Xin Yu ,

Contributed equally to this work with: Xin Yu, Zheng Li

Affiliations Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beilishi Road, Xicheng District, Beijing, China
⨯
Zheng Li ,

Contributed equally to this work with: Xin Yu, Zheng Li

Affiliation Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China
⨯
Jianxiong Shen ,

* E-mail: shenjianxiong@medmail.com.cn

Affiliation Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China
⨯
William K. K. Wu,

Affiliation Institute of Digestive Disease and State Key Laboratory of Digestive Disease, LKS Institute of Health Sciences & Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
⨯
Jinqian Liang,

Affiliation Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China
⨯
Xisheng Weng,

Affiliation Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China
⨯
Guixing Qiu

Affiliation Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China
⨯

MicroRNA-10b Promotes Nucleus Pulposus Cell Proliferation through RhoC-Akt Pathway by Targeting HOXD10 in Intervetebral Disc Degeneration

Xin Yu,
Zheng Li,
Jianxiong Shen,
William K. K. Wu,
Jinqian Liang,
Xisheng Weng,
Guixing Qiu

Published: December 20, 2013
https://doi.org/10.1371/journal.pone.0083080

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