Beauvericin Ameliorates Experimental Colitis by Inhibiting Activated T Cells via Downregulation of the PI3K/Akt Signaling Pathway

Xue-Feng Wu; Rui Xu; Zi-Jun Ouyang; Cheng Qian; Yan Shen; Xu-Dong Wu; Yan-Hong Gu; Qiang Xu; Yang Sun

doi:10.1371/journal.pone.0083013

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Open Access

Peer-reviewed

Research Article

Beauvericin Ameliorates Experimental Colitis by Inhibiting Activated T Cells via Downregulation of the PI3K/Akt Signaling Pathway

Xue-Feng Wu,

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu Province, China
⨯
Rui Xu,

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu Province, China
⨯
Zi-Jun Ouyang,

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu Province, China
⨯
Cheng Qian,

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu Province, China
⨯
Yan Shen,

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu Province, China
⨯
Xu-Dong Wu,

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu Province, China
⨯
Yan-Hong Gu,

Affiliation Department of Clinical Oncology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province, China
⨯
Qiang Xu ,

* E-mail: yangsun@nju.edu.cn (YS); molpharm@163.com (QX)

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu Province, China
⨯
Yang Sun

* E-mail: yangsun@nju.edu.cn (YS); molpharm@163.com (QX)

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu Province, China
⨯

Beauvericin Ameliorates Experimental Colitis by Inhibiting Activated T Cells via Downregulation of the PI3K/Akt Signaling Pathway

Xue-Feng Wu,
Rui Xu,
Zi-Jun Ouyang,
Cheng Qian,
Yan Shen,
Xu-Dong Wu,
Yan-Hong Gu,
Qiang Xu,
Yang Sun

Published: December 10, 2013
https://doi.org/10.1371/journal.pone.0083013

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