Fibroblast Growth Factor Receptor 1 Signaling in Adult Cardiomyocytes Increases Contractility and Results in a Hypertrophic Cardiomyopathy

Sarah N. Cilvik; Joy I. Wang; Kory J. Lavine; Keita Uchida; Angela Castro; Carolyn M. Gierasch; Carla J. Weinheimer; Stacey L. House; Attila Kovacs; Colin G. Nichols; David M. Ornitz

doi:10.1371/journal.pone.0082979

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Open Access

Peer-reviewed

Research Article

Fibroblast Growth Factor Receptor 1 Signaling in Adult Cardiomyocytes Increases Contractility and Results in a Hypertrophic Cardiomyopathy

Sarah N. Cilvik,

Affiliation Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Joy I. Wang,

Affiliation Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Kory J. Lavine,

Affiliation Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Keita Uchida,

Affiliation Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Angela Castro,

Affiliation Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Carolyn M. Gierasch,

Affiliation Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Carla J. Weinheimer,

Affiliation Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Stacey L. House,

Affiliations Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Division of Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Attila Kovacs,

Affiliation Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Colin G. Nichols,

Affiliation Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
David M. Ornitz

* E-mail: dornitz@wustl.edu

Affiliation Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯

Fibroblast Growth Factor Receptor 1 Signaling in Adult Cardiomyocytes Increases Contractility and Results in a Hypertrophic Cardiomyopathy

Sarah N. Cilvik,
Joy I. Wang,
Kory J. Lavine,
Keita Uchida,
Angela Castro,
Carolyn M. Gierasch,
Carla J. Weinheimer,
Stacey L. House,
Attila Kovacs,
Colin G. Nichols

Published: December 11, 2013
https://doi.org/10.1371/journal.pone.0082979

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