Elevated Levels of Interferon-γ Production by Memory T Cells Do Not Promote Transplant Tolerance Resistance in Aged Recipients

James I. Kim; Ryan T. Stott; Julie Soohoo; Kang Mi Lee; Gaoping Zhao; Heidi Yeh; Shaoping Deng; James F. Markmann

doi:10.1371/journal.pone.0082856

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Peer-reviewed

Research Article

Elevated Levels of Interferon-γ Production by Memory T Cells Do Not Promote Transplant Tolerance Resistance in Aged Recipients

James I. Kim,

Affiliation Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Ryan T. Stott,

Affiliation Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Julie Soohoo,

Affiliation Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Kang Mi Lee,

Affiliation Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Gaoping Zhao,

Affiliations Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Surgery, Sichuan Provincial People’s Hospital and Sichuan Academy of Medical Sciences, Chengdu, Sichuan Province, China
⨯
Heidi Yeh,

Affiliation Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Shaoping Deng,

Affiliations Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Surgery, Sichuan Provincial People’s Hospital and Sichuan Academy of Medical Sciences, Chengdu, Sichuan Province, China
⨯
James F. Markmann

* E-mail: jmarkmann@partners.org

Affiliation Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Elevated Levels of Interferon-γ Production by Memory T Cells Do Not Promote Transplant Tolerance Resistance in Aged Recipients

James I. Kim,
Ryan T. Stott,
Julie Soohoo,
Kang Mi Lee,
Gaoping Zhao,
Heidi Yeh,
Shaoping Deng,
James F. Markmann

Published: December 10, 2013
https://doi.org/10.1371/journal.pone.0082856

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T cells
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Skin grafting
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Cytotoxic T cells
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Castration
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Memory T cells
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Antibody therapy
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Graft survival
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Transplant rejection
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