A Vaccine That Co-Targets Tumor Cells and Cancer Associated Fibroblasts Results in Enhanced Antitumor Activity by Inducing Antigen Spreading

Stephen Gottschalk; Feng Yu; Minjun Ji; Sunitha Kakarla; Xiao-Tong Song

doi:10.1371/journal.pone.0082658

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Research Article

A Vaccine That Co-Targets Tumor Cells and Cancer Associated Fibroblasts Results in Enhanced Antitumor Activity by Inducing Antigen Spreading

Stephen Gottschalk ,

* E-mail: xxtongso@txch.org (XTS); smgottsc@txch.org (SG)

Affiliations Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, Texas, United States of America, Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America, Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, United States of America, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America, Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Feng Yu,

Affiliation Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Minjun Ji,

Affiliation Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Sunitha Kakarla,

Affiliations Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, Texas, United States of America, Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Xiao-Tong Song

* E-mail: xxtongso@txch.org (XTS); smgottsc@txch.org (SG)

Affiliations Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, Texas, United States of America, Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America
⨯

A Vaccine That Co-Targets Tumor Cells and Cancer Associated Fibroblasts Results in Enhanced Antitumor Activity by Inducing Antigen Spreading

Stephen Gottschalk,
Feng Yu,
Minjun Ji,
Sunitha Kakarla,
Xiao-Tong Song

Published: December 12, 2013
https://doi.org/10.1371/journal.pone.0082658

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