Hypoxia/Aglycemia-Induced Endothelial Barrier Dysfunction and Tight Junction Protein Downregulation Can Be Ameliorated by Citicoline

Xiaotang Ma; Huiting Zhang; Qunwen Pan; Yuhui Zhao; Ji Chen; Bin Zhao; Yanfang Chen

doi:10.1371/journal.pone.0082604

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Peer-reviewed

Research Article

Hypoxia/Aglycemia-Induced Endothelial Barrier Dysfunction and Tight Junction Protein Downregulation Can Be Ameliorated by Citicoline

Xiaotang Ma ,

Contributed equally to this work with: Xiaotang Ma, Huiting Zhang

Affiliation Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China
⨯
Huiting Zhang ,

Contributed equally to this work with: Xiaotang Ma, Huiting Zhang

Affiliation Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China
⨯
Qunwen Pan,

Affiliation Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China
⨯
Yuhui Zhao,

Affiliation Department of Pharmacology & Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, United States of America
⨯
Ji Chen,

Affiliations Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China, Department of Pharmacology & Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, United States of America
⨯
Bin Zhao ,

* E-mail: yanfang.chen@wright.edu (YC); zhaobine@163.net (BZ)

Affiliation Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China
⨯
Yanfang Chen

* E-mail: yanfang.chen@wright.edu (YC); zhaobine@163.net (BZ)

Affiliations Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China, Department of Pharmacology & Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, United States of America
⨯

Hypoxia/Aglycemia-Induced Endothelial Barrier Dysfunction and Tight Junction Protein Downregulation Can Be Ameliorated by Citicoline

Xiaotang Ma,
Huiting Zhang,
Qunwen Pan,
Yuhui Zhao,
Ji Chen,
Bin Zhao,
Yanfang Chen

Published: December 16, 2013
https://doi.org/10.1371/journal.pone.0082604

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Hypoxia
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Endothelial cells
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Permeability
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Medical hypoxia
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Blood-brain barrier
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Gene expression
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Tight junctions
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