Impact of Perinatal Systemic Hypoxic–Ischemic Injury on the Brain of Male Offspring Rats: An Improved Model of Neonatal Hypoxic–Ischemic Encephalopathy in Early Preterm Newborns

Yuejun Huang; Huihong Lai; Hongwu Xu; Weizhao Wu; Xiulan Lai; Guyu Ho; Lian Ma; Yunbin Chen

doi:10.1371/journal.pone.0082502

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Peer-reviewed

Research Article

Impact of Perinatal Systemic Hypoxic–Ischemic Injury on the Brain of Male Offspring Rats: An Improved Model of Neonatal Hypoxic–Ischemic Encephalopathy in Early Preterm Newborns

Yuejun Huang ,

Contributed equally to this work with: Yuejun Huang, Huihong Lai

Affiliations Transforming Medical Center, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China, Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China
⨯
Huihong Lai ,

Contributed equally to this work with: Yuejun Huang, Huihong Lai

Affiliation Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China
⨯
Hongwu Xu,

Affiliations Transforming Medical Center, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China, Department of Neurosurgery, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China
⨯
Weizhao Wu,

Affiliation Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China
⨯
Xiulan Lai,

Affiliation Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China
⨯
Guyu Ho,

Affiliation Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China
⨯
Lian Ma ,

* E-mail: malian8965@sina.com (LM); yunbin_chen@hotmail.com (YC)

Affiliations Transforming Medical Center, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China, Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China
⨯
Yunbin Chen

* E-mail: malian8965@sina.com (LM); yunbin_chen@hotmail.com (YC)

Affiliation Maternal and Child Health Hospital of Guangdong Province, Guangzhou, Guangdong, China
⨯

Impact of Perinatal Systemic Hypoxic–Ischemic Injury on the Brain of Male Offspring Rats: An Improved Model of Neonatal Hypoxic–Ischemic Encephalopathy in Early Preterm Newborns

Yuejun Huang,
Huihong Lai,
Hongwu Xu,
Weizhao Wu,
Xiulan Lai,
Guyu Ho,
Lian Ma,
Yunbin Chen

Published: December 6, 2013
https://doi.org/10.1371/journal.pone.0082502

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