Resistance to Bleomycin in Cancer Cell Lines Is Characterized by Prolonged Doubling Time, Reduced DNA Damage and Evasion of G2/M Arrest and Apoptosis

• Qi Wang ,

  Contributed equally to this work with: Qi Wang, Kangping Cui

  Affiliation Department of Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ontario, Canada

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• Kangping Cui ,

  Contributed equally to this work with: Qi Wang, Kangping Cui

  Affiliation Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada

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• Osvaldo Espin-Garcia,

  Affiliations Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada, Department of Biostatistics, Princess Margaret Hospital, Toronto, Ontario, Canada

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• Dangxiao Cheng,

  Affiliation Department of Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ontario, Canada

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• Xiaoping Qiu,

  Affiliation Institute of Virology, Medical School of Wuhan University, Wuhan, Hubei, China

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• Zhuo Chen,

  Affiliation Department of Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ontario, Canada

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• Malcolm Moore,

  Affiliations Department of Medicine and Pharmacology, University of Toronto, Toronto, Ontario, Canada, Division of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, Ontario, Canada

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• Robert G. Bristow,

  Affiliations Department of Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ontario, Canada, Departments of Medical Biophysics and Radiation Oncology, University of Toronto, Toronto, Ontario, Canada

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• Wei Xu,

  Affiliations Department of Biostatistics, Princess Margaret Hospital, Toronto, Ontario, Canada, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

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• Sandy Der,

  Affiliation Department of Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ontario, Canada

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• Geoffrey Liu

  * E-mail: Geoffrey.Liu@uhn.ca

  Affiliations Division of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, Ontario, Canada, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

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