Estimation of the Fraction of Cancer Cells in a Tumor DNA Sample Using DNA Methylation

• Takamasa Takahashi,

  Affiliations Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan, Esophageal Surgery Division, National Cancer Center Hospital, Tokyo, Japan, Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan

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• Yasunori Matsuda,

  Affiliations Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan, Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka City University, Osaka, Japan

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• Satoshi Yamashita,

  Affiliation Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan

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• Naoko Hattori,

  Affiliation Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan

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• Ryoji Kushima,

  Affiliation Pathology and Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan

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• Yi-Chia Lee,

  Affiliation Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan

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• Hiroyasu Igaki,

  Affiliation Esophageal Surgery Division, National Cancer Center Hospital, Tokyo, Japan

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• Yuji Tachimori,

  Affiliation Esophageal Surgery Division, National Cancer Center Hospital, Tokyo, Japan

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• Masato Nagino,

  Affiliation Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan

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• Toshikazu Ushijima

  * E-mail: tushijim@ncc.go.jp

  Affiliation Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan

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