Molecular Mechanism of Inhibition of the Mitochondrial Carnitine/Acylcarnitine Transporter by Omeprazole Revealed by Proteoliposome Assay, Mutagenesis and Bioinformatics

Open Access

Peer-reviewed

Research Article

Annamaria Tonazzi,

Affiliation CNR Institute of Biomembranes and Bioenergetics, Bari, Italy
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Ivano Eberini,

Affiliation Laboratorio di Biochimica e Biofisica Computazionale, Dipartimento di Scienze Farmacologiche e Biomolecolari, Sezione di Biochimica, Biofisica, Fisiologia ed Immunopatologia, Università degli Studi di Milano, Milano, Italy
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Cesare Indiveri

* E-mail: indiveri@unical.it

Affiliations CNR Institute of Biomembranes and Bioenergetics, Bari, Italy, Department BEST (Biologia, Ecologia, Scienze della Terra), Unit of Biochemistry and Molecular Biotechnology, University of Calabria, Arcavacata di Rende, Italy
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Drug interactions
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Transport inhibition assay
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Mitochondria
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Membrane proteins
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Molecular docking
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Radioactivity
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Cell membranes
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Liposomes
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