Resistance to ROS1 Inhibition Mediated by EGFR Pathway Activation in Non-Small Cell Lung Cancer

Kurtis D. Davies; Sakshi Mahale; David P. Astling; Dara L. Aisner; Anh T. Le; Trista K. Hinz; Aria Vaishnavi; Paul A. Bunn Jr; Lynn E. Heasley; Aik-Choon Tan; D. Ross Camidge; Marileila Varella-Garcia; Robert C. Doebele

doi:10.1371/journal.pone.0082236

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Open Access

Peer-reviewed

Research Article

Resistance to ROS1 Inhibition Mediated by EGFR Pathway Activation in Non-Small Cell Lung Cancer

Kurtis D. Davies,

Affiliation Department of Medicine, Division of Medical Oncology, University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Sakshi Mahale,

Affiliation Department of Medicine, Division of Medical Oncology, University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
David P. Astling,

Affiliation Department of Medicine, Division of Medical Oncology, University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Dara L. Aisner,

Affiliation Department of Pathology, University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Anh T. Le,

Affiliation Department of Medicine, Division of Medical Oncology, University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Trista K. Hinz,

Affiliation Department of Craniofacial Biology, University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Aria Vaishnavi,

Affiliation Department of Medicine, Division of Medical Oncology, University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Paul A. Bunn Jr,

Affiliation Department of Medicine, Division of Medical Oncology, University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Lynn E. Heasley,

Affiliation Department of Craniofacial Biology, University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Aik-Choon Tan,

Affiliation Department of Medicine, Division of Medical Oncology, University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
D. Ross Camidge,

Affiliation Department of Medicine, Division of Medical Oncology, University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Marileila Varella-Garcia,

Affiliation Department of Medicine, Division of Medical Oncology, University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Robert C. Doebele

* E-mail: robert.doebele@ucdenver.edu

Affiliation Department of Medicine, Division of Medical Oncology, University of Colorado - Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯

Resistance to ROS1 Inhibition Mediated by EGFR Pathway Activation in Non-Small Cell Lung Cancer

Kurtis D. Davies,
Sakshi Mahale,
David P. Astling,
Dara L. Aisner,
Anh T. Le,
Trista K. Hinz,
Aria Vaishnavi,
Paul A. Bunn Jr,
Lynn E. Heasley,
Aik-Choon Tan

Published: December 13, 2013
https://doi.org/10.1371/journal.pone.0082236

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Non-small cell lung cancer
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Cell fusion
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EGFR signaling
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Fusion genes
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Cancer treatment
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Signal inhibition
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