ICOS Regulates the Generation and Function of Human CD4+ Treg in a CTLA-4 Dependent Manner

Open Access

Peer-reviewed

Research Article

ICOS Regulates the Generation and Function of Human CD4⁺ Treg in a CTLA-4 Dependent Manner

Jian Zheng,

Affiliation Department of Pediatrics and Adolescent Medicine, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, PR China
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Ping-Lung Chan,

Affiliation Department of Pediatrics and Adolescent Medicine, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, PR China
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Yinping Liu,

Affiliation Department of Pediatrics and Adolescent Medicine, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, PR China
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Gang Qin,

Affiliation Department of Pediatrics and Adolescent Medicine, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, PR China
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Zheng Xiang,

Affiliation Department of Pediatrics and Adolescent Medicine, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, PR China
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Kwok-Tai Lam,

Affiliation Department of Pediatrics and Adolescent Medicine, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, PR China
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David B. Lewis,

Affiliation Division of Immunology and Allergy, Department of Pediatrics, School of Medicine, Stanford University, Stanford, California, United States of America
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Yu-Lung Lau,

Affiliation Department of Pediatrics and Adolescent Medicine, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, PR China
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Wenwei Tu

* E-mail: wwtu@hkucc.hku.hk

Affiliation Department of Pediatrics and Adolescent Medicine, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, PR China
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Regulatory T cells
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T cells
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B cells
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Protease inhibitor therapy
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Apoptosis
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Endocytosis
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Cell staining
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Exocytosis
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