Inhibition of Mitochondrial Complex III Blocks Neuronal Differentiation and Maintains Embryonic Stem Cell Pluripotency

Sandro L. Pereira; Mário Grãos; Ana Sofia Rodrigues; Sandra I. Anjo; Rui A. Carvalho; Paulo J. Oliveira; Ernest Arenas; João Ramalho-Santos

doi:10.1371/journal.pone.0082095

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Peer-reviewed

Research Article

Inhibition of Mitochondrial Complex III Blocks Neuronal Differentiation and Maintains Embryonic Stem Cell Pluripotency

Sandro L. Pereira,

Affiliations CNC- Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal
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Mário Grãos,

Affiliation Biocant – Technology Transfer Association, Cantanhede, Portugal
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Ana Sofia Rodrigues,

Affiliations CNC- Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal
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Sandra I. Anjo,

Affiliations CNC- Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal
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Rui A. Carvalho,

Affiliations CNC- Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal
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Paulo J. Oliveira,

Affiliations CNC- Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal
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Ernest Arenas,

Affiliation Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
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João Ramalho-Santos

* E-mail: jramalho@ci.uc.pt

Affiliations CNC- Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal
⨯

Inhibition of Mitochondrial Complex III Blocks Neuronal Differentiation and Maintains Embryonic Stem Cell Pluripotency

Sandro L. Pereira,
Mário Grãos,
Ana Sofia Rodrigues,
Sandra I. Anjo,
Rui A. Carvalho,
Paulo J. Oliveira,
Ernest Arenas,
João Ramalho-Santos

Published: December 2, 2013
https://doi.org/10.1371/journal.pone.0082095

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Neuronal differentiation
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Mitochondria
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Cell differentiation
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Pluripotency
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