Ursodeoxycholic Acid but Not Tauroursodeoxycholic Acid Inhibits Proliferation and Differentiation of Human Subcutaneous Adipocytes

Lucia Mališová; Zuzana Kováčová; Michal Koc; Jana Kračmerová; Vladimír Štich; Lenka Rossmeislová

doi:10.1371/journal.pone.0082086

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Research Article

Ursodeoxycholic Acid but Not Tauroursodeoxycholic Acid Inhibits Proliferation and Differentiation of Human Subcutaneous Adipocytes

Lucia Mališová,

Affiliations Department of Sport Medicine, Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, Franco-Czech Laboratory for Clinical Research on Obesity, Third Faculty of Medicine, Prague, Czech Republic, INSERM, Toulouse, France
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Zuzana Kováčová,

Affiliations Department of Sport Medicine, Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, Franco-Czech Laboratory for Clinical Research on Obesity, Third Faculty of Medicine, Prague, Czech Republic, INSERM, Toulouse, France
⨯
Michal Koc,

Affiliations Department of Sport Medicine, Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, Franco-Czech Laboratory for Clinical Research on Obesity, Third Faculty of Medicine, Prague, Czech Republic, INSERM, Toulouse, France
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Jana Kračmerová,

Affiliations Department of Sport Medicine, Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, Franco-Czech Laboratory for Clinical Research on Obesity, Third Faculty of Medicine, Prague, Czech Republic, INSERM, Toulouse, France
⨯
Vladimír Štich,

Affiliations Department of Sport Medicine, Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, Franco-Czech Laboratory for Clinical Research on Obesity, Third Faculty of Medicine, Prague, Czech Republic, INSERM, Toulouse, France
⨯
Lenka Rossmeislová

* E-mail: Lenka.Rossmeislova@lf3.cuni.cz

Affiliations Department of Sport Medicine, Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, Franco-Czech Laboratory for Clinical Research on Obesity, Third Faculty of Medicine, Prague, Czech Republic, INSERM, Toulouse, France
⨯

Ursodeoxycholic Acid but Not Tauroursodeoxycholic Acid Inhibits Proliferation and Differentiation of Human Subcutaneous Adipocytes

Lucia Mališová,
Zuzana Kováčová,
Michal Koc,
Jana Kračmerová,
Vladimír Štich,
Lenka Rossmeislová

Published: December 3, 2013
https://doi.org/10.1371/journal.pone.0082086

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Adipocytes
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Adipocyte differentiation
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Gene expression
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Endoplasmic reticulum
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Obesity
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Insulin
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Cell differentiation
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Inflammation
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