Probing the Effect of the Non-Active-Site Mutation Y229W in New Delhi Metallo-β-lactamase-1 by Site-Directed Mutagenesis, Kinetic Studies, and Molecular Dynamics Simulations

• Jiao Chen ,

  Contributed equally to this work with: Jiao Chen, Hui Chen

  Affiliation School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China

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• Hui Chen ,

  Contributed equally to this work with: Jiao Chen, Hui Chen

  Affiliation School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China

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• Yun Shi,

  Affiliation School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China

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• Feng Hu,

  Affiliation School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China

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• Xingzhen Lao,

  Affiliation School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China

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• Xiangdong Gao,

  Affiliation School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China

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• Heng Zheng ,

  * E-mail: zhengh18@hotmail.com (HZ); wbyao@cpu.edu.cn (WY)

  Affiliation School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China

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• Wenbing Yao

  * E-mail: zhengh18@hotmail.com (HZ); wbyao@cpu.edu.cn (WY)

  Affiliation School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China

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