Smooth Muscle LDL Receptor-Related Protein-1 Deletion Induces Aortic Insufficiency and Promotes Vascular Cardiomyopathy in Mice

Joshua E. Basford; Sheryl Koch; Ahmad Anjak; Vivek P. Singh; Eric G. Krause; Nathan Robbins; Neal L. Weintraub; David Y. Hui; Jack Rubinstein

doi:10.1371/journal.pone.0082026

Loading metrics

Open Access

Peer-reviewed

Research Article

Smooth Muscle LDL Receptor-Related Protein-1 Deletion Induces Aortic Insufficiency and Promotes Vascular Cardiomyopathy in Mice

Joshua E. Basford,

Affiliation Department of Pathology, Metabolic Diseases Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯
Sheryl Koch,

Affiliation Department of Internal Medicine, Division of Cardiovascular Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯
Ahmad Anjak,

Affiliation Department of Internal Medicine, Division of Cardiovascular Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯
Vivek P. Singh,

Affiliation Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯
Eric G. Krause,

Current address: Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida, United States of America

Affiliation Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯
Nathan Robbins,

Affiliation Department of Internal Medicine, Division of Cardiovascular Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯
Neal L. Weintraub,

Current address: Vascular Biology Center, Georgia Regents University, Augusta, Georgia, United States of America

Affiliation Department of Internal Medicine, Division of Cardiovascular Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯
David Y. Hui ,

* E-mail: huidy@ucmail.uc.edu (DYH); rubinsjk@ucmail.uc.edu (JR)

Affiliation Department of Pathology, Metabolic Diseases Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯
Jack Rubinstein

* E-mail: huidy@ucmail.uc.edu (DYH); rubinsjk@ucmail.uc.edu (JR)

Affiliation Department of Internal Medicine, Division of Cardiovascular Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯

Smooth Muscle LDL Receptor-Related Protein-1 Deletion Induces Aortic Insufficiency and Promotes Vascular Cardiomyopathy in Mice

Joshua E. Basford,
Sheryl Koch,
Ahmad Anjak,
Vivek P. Singh,
Eric G. Krause,
Nathan Robbins,
Neal L. Weintraub,
David Y. Hui,
Jack Rubinstein

Published: November 29, 2013
https://doi.org/10.1371/journal.pone.0082026

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Aorta
Is the Subject Area "Aorta" applicable to this article?

Thanks for your feedback.
Blood pressure
Is the Subject Area "Blood pressure" applicable to this article?

Thanks for your feedback.
Heart
Is the Subject Area "Heart" applicable to this article?

Thanks for your feedback.
Marfan syndrome
Is the Subject Area "Marfan syndrome" applicable to this article?

Thanks for your feedback.
Cardiomyopathies
Is the Subject Area "Cardiomyopathies" applicable to this article?

Thanks for your feedback.
Coronary arteries
Is the Subject Area "Coronary arteries" applicable to this article?

Thanks for your feedback.
Smooth muscles
Is the Subject Area "Smooth muscles" applicable to this article?

Thanks for your feedback.