Concerted Suppression of STAT3 and GSK3β Is Involved in Growth Inhibition of Non-Small Cell Lung Cancer by Xanthatin

Li Tao; Fangtian Fan; Yuping Liu; Weidong Li; Lei Zhang; Junshan Ruan; Cunsi Shen; Xiaobo Sheng; Zhijie Zhu; Aiyun Wang; Wenxing Chen; Shile Huang; Yin Lu

doi:10.1371/journal.pone.0081945

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Open Access

Peer-reviewed

Research Article

Concerted Suppression of STAT3 and GSK3β Is Involved in Growth Inhibition of Non-Small Cell Lung Cancer by Xanthatin

Li Tao,

Affiliation Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Fangtian Fan,

Affiliation Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Yuping Liu,

Affiliation Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Weidong Li,

Affiliation Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Lei Zhang,

Affiliation Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Junshan Ruan,

Affiliation Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Cunsi Shen,

Affiliation Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Xiaobo Sheng,

Affiliation Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Zhijie Zhu,

Affiliation Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Aiyun Wang,

Affiliations Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Wenxing Chen,

Affiliations Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China
⨯
Shile Huang,

Affiliation Department of Biochemistry and Molecular Biology, Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯
Yin Lu

* E-mail: profyinlu@163.com

Affiliations Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China, Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China
⨯

Concerted Suppression of STAT3 and GSK3β Is Involved in Growth Inhibition of Non-Small Cell Lung Cancer by Xanthatin

Li Tao,
Fangtian Fan,
Yuping Liu,
Weidong Li,
Lei Zhang,
Junshan Ruan,
Cunsi Shen,
Xiaobo Sheng,
Zhijie Zhu,
Aiyun Wang

Published: November 28, 2013
https://doi.org/10.1371/journal.pone.0081945

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Non-small cell lung cancer
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Small interfering RNA
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Apoptosis
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Transfection
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Luciferase
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STAT signaling
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Signal inhibition
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