In Vitro and In Vivo Evaluation of a 18F-Labeled High Affinity NOTA Conjugated Bombesin Antagonist as a PET Ligand for GRPR-Targeted Tumor Imaging

Zohreh Varasteh; Ola Åberg; Irina Velikyan; Gunnar Lindeberg; Jens Sörensen; Mats Larhed; Gunnar Antoni; Mattias Sandström; Vladimir Tolmachev; Anna Orlova

doi:10.1371/journal.pone.0081932

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Peer-reviewed

Research Article

In Vitro and In Vivo Evaluation of a ¹⁸F-Labeled High Affinity NOTA Conjugated Bombesin Antagonist as a PET Ligand for GRPR-Targeted Tumor Imaging

Zohreh Varasteh ,

Contributed equally to this work with: Zohreh Varasteh, Ola Åberg

* E-mail: zohreh.varasteh@pet.medchem.uu.se

Affiliation Preclinical PET Platform, Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Uppsala, Sweden
⨯
Ola Åberg ,

Contributed equally to this work with: Zohreh Varasteh, Ola Åberg

Affiliation Preclinical PET Platform, Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Uppsala, Sweden
⨯
Irina Velikyan,

Affiliations Preclinical PET Platform, Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Uppsala, Sweden, Biomedical Radiation Sciences, Department of Radiology, Oncology and Radiation Sciences, Faculty of Medicine, Uppsala University, Uppsala, Sweden, PET Centre, Centre for Medical Imaging, Uppsala University Hospital, Uppsala, Sweden
⨯
Gunnar Lindeberg,

Affiliation Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Uppsala, Sweden
⨯
Jens Sörensen,

Affiliations Biomedical Radiation Sciences, Department of Radiology, Oncology and Radiation Sciences, Faculty of Medicine, Uppsala University, Uppsala, Sweden, PET Centre, Centre for Medical Imaging, Uppsala University Hospital, Uppsala, Sweden
⨯
Mats Larhed,

Affiliation Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Uppsala, Sweden
⨯
Gunnar Antoni,

Affiliations Preclinical PET Platform, Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Uppsala, Sweden, PET Centre, Centre for Medical Imaging, Uppsala University Hospital, Uppsala, Sweden
⨯
Mattias Sandström,

Affiliation PET Centre, Centre for Medical Imaging, Uppsala University Hospital, Uppsala, Sweden
⨯
Vladimir Tolmachev,

Affiliation Biomedical Radiation Sciences, Department of Radiology, Oncology and Radiation Sciences, Faculty of Medicine, Uppsala University, Uppsala, Sweden
⨯
Anna Orlova

Affiliation Preclinical PET Platform, Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Uppsala, Sweden
⨯

In Vitro and In Vivo Evaluation of a ¹⁸F-Labeled High Affinity NOTA Conjugated Bombesin Antagonist as a PET Ligand for GRPR-Targeted Tumor Imaging

Zohreh Varasteh,
Ola Åberg,
Irina Velikyan,
Gunnar Lindeberg,
Jens Sörensen,
Mats Larhed,
Gunnar Antoni,
Mattias Sandström,
Vladimir Tolmachev,
Anna Orlova

Published: December 3, 2013
https://doi.org/10.1371/journal.pone.0081932

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