Hypoxic Tumor Environments Exhibit Disrupted Collagen I Fibers and Low Macromolecular Transport

Samata M. Kakkad; Marie-France Penet; Alireza Akhbardeh; Arvind P. Pathak; Meiyappan Solaiyappan; Venu Raman; Dieter Leibfritz; Kristine Glunde; Zaver M. Bhujwalla

doi:10.1371/journal.pone.0081869

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Peer-reviewed

Research Article

Hypoxic Tumor Environments Exhibit Disrupted Collagen I Fibers and Low Macromolecular Transport

Samata M. Kakkad,

Affiliations JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Universität Bremen, Fachbereich 2, Bremen, Germany
⨯
Marie-France Penet,

Affiliation JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Alireza Akhbardeh,

Affiliation JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Arvind P. Pathak,

Affiliations JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Meiyappan Solaiyappan,

Affiliation JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Venu Raman,

Affiliations JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Dieter Leibfritz,

Affiliation Universität Bremen, Fachbereich 2, Bremen, Germany
⨯
Kristine Glunde,

Affiliations JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Zaver M. Bhujwalla

* E-mail: zaver@mri.jhu.edu

Affiliations JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯

Hypoxic Tumor Environments Exhibit Disrupted Collagen I Fibers and Low Macromolecular Transport

Samata M. Kakkad,
Marie-France Penet,
Alireza Akhbardeh,
Arvind P. Pathak,
Meiyappan Solaiyappan,
Venu Raman,
Dieter Leibfritz,
Kristine Glunde,
Zaver M. Bhujwalla

Published: December 12, 2013
https://doi.org/10.1371/journal.pone.0081869

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