Topoisomerase I Inhibitors, Shikonin and Topotecan, Inhibit Growth and Induce Apoptosis of Glioma Cells and Glioma Stem Cells

Feng-Lei Zhang; Ping Wang; Yun-Hui Liu; Li-bo Liu; Xiao-Bai Liu; Zhen Li; Yi-Xue Xue

doi:10.1371/journal.pone.0081815

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Peer-reviewed

Research Article

Topoisomerase I Inhibitors, Shikonin and Topotecan, Inhibit Growth and Induce Apoptosis of Glioma Cells and Glioma Stem Cells

Feng-Lei Zhang ,

Contributed equally to this work with: Feng-Lei Zhang, Ping Wang

Affiliations Department of Neurobiology, College of Basic Medicine, China Medical University, Shenyang, Liaoning Province, People’s Republic of China, Institute of Pathology and Pathophysiology, China Medical University, Shenyang, Liaoning Province, People’s Republic of China
⨯
Ping Wang ,

Contributed equally to this work with: Feng-Lei Zhang, Ping Wang

Affiliations Department of Neurobiology, College of Basic Medicine, China Medical University, Shenyang, Liaoning Province, People’s Republic of China, Institute of Pathology and Pathophysiology, China Medical University, Shenyang, Liaoning Province, People’s Republic of China
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Yun-Hui Liu,

Affiliation Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of China
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Li-bo Liu,

Affiliations Department of Neurobiology, College of Basic Medicine, China Medical University, Shenyang, Liaoning Province, People’s Republic of China, Institute of Pathology and Pathophysiology, China Medical University, Shenyang, Liaoning Province, People’s Republic of China
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Xiao-Bai Liu,

Affiliation 96th Class, 7-Year Program, China Medical University, Shenyang, Liaoning Province, People’s Republic of China
⨯
Zhen Li,

Affiliation Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of China
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Yi-Xue Xue

* E-mail: xueyixue888@163.com

Affiliations Department of Neurobiology, College of Basic Medicine, China Medical University, Shenyang, Liaoning Province, People’s Republic of China, Institute of Pathology and Pathophysiology, China Medical University, Shenyang, Liaoning Province, People’s Republic of China
⨯

Topoisomerase I Inhibitors, Shikonin and Topotecan, Inhibit Growth and Induce Apoptosis of Glioma Cells and Glioma Stem Cells

Feng-Lei Zhang,
Ping Wang,
Yun-Hui Liu,
Li-bo Liu,
Xiao-Bai Liu,
Zhen Li,
Yi-Xue Xue

Published: November 26, 2013
https://doi.org/10.1371/journal.pone.0081815

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Cell cycle and cell division
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