Mutational Analysis of Sclerostin Shows Importance of the Flexible Loop and the Cystine-Knot for Wnt-Signaling Inhibition

Open Access

Peer-reviewed

Research Article

Verena Boschert,

Affiliation Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs Institute of the University Wuerzburg, Wuerzburg, Germany
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Maarten van Dinther,

Affiliation Department of Molecular Cell Biology, Cancer Genomics Center Netherlands and Center for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
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Stella Weidauer,

Affiliation Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs Institute of the University Wuerzburg, Wuerzburg, Germany
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Katharina van Pee,

Affiliation Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs Institute of the University Wuerzburg, Wuerzburg, Germany
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Eva-Maria Muth,

Affiliation Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs Institute of the University Wuerzburg, Wuerzburg, Germany
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Peter ten Dijke,

Affiliation Department of Molecular Cell Biology, Cancer Genomics Center Netherlands and Center for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
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Thomas D. Mueller

* E-mail: mueller@biozentrum.uni-wuerzburg.de

Affiliation Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs Institute of the University Wuerzburg, Wuerzburg, Germany
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Transfection
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Wnt signaling cascade
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Binding analysis
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Osteoblasts
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Biological locomotion
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Signal inhibition
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Luciferase
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Cell binding assay
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