Effectors of Epidermal Growth Factor Receptor Pathway: The Genetic Profiling of KRAS, BRAF, PIK3CA, NRAS Mutations in Colorectal Cancer Characteristics and Personalized Medicine

Yinchen Shen; Jianfei Wang; Xiaohong Han; Hongying Yang; Shuai Wang; Dongmei Lin; Yuankai Shi

doi:10.1371/journal.pone.0081628

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Peer-reviewed

Research Article

Effectors of Epidermal Growth Factor Receptor Pathway: The Genetic Profiling of KRAS, BRAF, PIK3CA, NRAS Mutations in Colorectal Cancer Characteristics and Personalized Medicine

Yinchen Shen ,

Contributed equally to this work with: Yinchen Shen, Jianfei Wang

Affiliations Department of Medical Oncology, Cancer Institute/Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Beijing, China
⨯
Jianfei Wang ,

Contributed equally to this work with: Yinchen Shen, Jianfei Wang

Affiliations Department of Medical Oncology, Cancer Institute/Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Beijing, China
⨯
Xiaohong Han,

Affiliations Department of Medical Oncology, Cancer Institute/Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Beijing, China
⨯
Hongying Yang,

Affiliation Department of Pathology, Cancer Institute/Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
⨯
Shuai Wang,

Affiliations Department of Medical Oncology, Cancer Institute/Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Beijing, China
⨯
Dongmei Lin,

Affiliation Department of Pathology, Cancer Institute/Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
⨯
Yuankai Shi

* E-mail: syuankaipumc@126.com

Affiliations Department of Medical Oncology, Cancer Institute/Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Beijing, China
⨯

Effectors of Epidermal Growth Factor Receptor Pathway: The Genetic Profiling of KRAS, BRAF, PIK3CA, NRAS Mutations in Colorectal Cancer Characteristics and Personalized Medicine

Yinchen Shen,
Jianfei Wang,
Xiaohong Han,
Hongying Yang,
Shuai Wang,
Dongmei Lin,
Yuankai Shi

Published: December 10, 2013
https://doi.org/10.1371/journal.pone.0081628

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