A Systematic Evaluation of Integration Free Reprogramming Methods for Deriving Clinically Relevant Patient Specific Induced Pluripotent Stem (iPS) Cells

Pollyanna A. Goh; Sara Caxaria; Catharina Casper; Cecilia Rosales; Thomas T. Warner; Pete J. Coffey; Amit C. Nathwani

doi:10.1371/journal.pone.0081622

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Peer-reviewed

Research Article

A Systematic Evaluation of Integration Free Reprogramming Methods for Deriving Clinically Relevant Patient Specific Induced Pluripotent Stem (iPS) Cells

Pollyanna A. Goh,

Affiliations Research Department of Haematology, University College London Cancer Institute, University College London, London, United Kingdom, National Health Service Blood and Transplant Unit, National Health Service, London, United Kingdom
⨯
Sara Caxaria,

Affiliations Research Department of Haematology, University College London Cancer Institute, University College London, London, United Kingdom, National Health Service Blood and Transplant Unit, National Health Service, London, United Kingdom
⨯
Catharina Casper,

Affiliation Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, United Kingdom
⨯
Cecilia Rosales,

Affiliations Research Department of Haematology, University College London Cancer Institute, University College London, London, United Kingdom, National Health Service Blood and Transplant Unit, National Health Service, London, United Kingdom
⨯
Thomas T. Warner,

Affiliation Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, United Kingdom
⨯
Pete J. Coffey,

Affiliation Ocular Biology and Therapeutics, Institute of Ophthalmology, University College London, London, United Kingdom
⨯
Amit C. Nathwani

* E-mail: amit.nathwani@ucl.ac.uk

Affiliations Research Department of Haematology, University College London Cancer Institute, University College London, London, United Kingdom, National Health Service Blood and Transplant Unit, National Health Service, London, United Kingdom, Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free Hospital, London, United Kingdom
⨯

A Systematic Evaluation of Integration Free Reprogramming Methods for Deriving Clinically Relevant Patient Specific Induced Pluripotent Stem (iPS) Cells

Pollyanna A. Goh,
Sara Caxaria,
Catharina Casper,
Cecilia Rosales,
Thomas T. Warner,
Pete J. Coffey,
Amit C. Nathwani

Published: November 26, 2013
https://doi.org/10.1371/journal.pone.0081622

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Fibroblasts
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Induced pluripotent stem cells
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Pluripotency
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Cultured fibroblasts
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Transfection
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Plasmid construction
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Cell differentiation
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