Gram-Positive Bacterial Lipoglycans Based on a Glycosylated Diacylglycerol Lipid Anchor Are Microbe-Associated Molecular Patterns Recognized by TLR2

Landry Blanc; Romain Castanier; Arun K. Mishra; Aurélie Ray; Gurdyal S. Besra; Iain Sutcliffe; Alain Vercellone; Jérôme Nigou

doi:10.1371/journal.pone.0081593

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Peer-reviewed

Research Article

Gram-Positive Bacterial Lipoglycans Based on a Glycosylated Diacylglycerol Lipid Anchor Are Microbe-Associated Molecular Patterns Recognized by TLR2

Landry Blanc ,

Contributed equally to this work with: Landry Blanc, Romain Castanier

Affiliations CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale); 205 route de Narbonne, F-31077 Toulouse, France, Université de Toulouse; UPS; IPBS; F-31077 Toulouse, France
⨯
Romain Castanier ,

Contributed equally to this work with: Landry Blanc, Romain Castanier

Affiliations CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale); 205 route de Narbonne, F-31077 Toulouse, France, Université de Toulouse; UPS; IPBS; F-31077 Toulouse, France
⨯
Arun K. Mishra,

Affiliation National Institute for Medical Research, London, United Kingdom
⨯
Aurélie Ray,

Current address: Transgene S.A., Illkirch-Graffenstaden, France

Affiliations CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale); 205 route de Narbonne, F-31077 Toulouse, France, Université de Toulouse; UPS; IPBS; F-31077 Toulouse, France
⨯
Gurdyal S. Besra,

Affiliation School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
⨯
Iain Sutcliffe,

Affiliation Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom
⨯
Alain Vercellone,

Affiliations CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale); 205 route de Narbonne, F-31077 Toulouse, France, Université de Toulouse; UPS; IPBS; F-31077 Toulouse, France
⨯
Jérôme Nigou

* E-mail: jerome.nigou@ipbs.fr

Affiliations CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale); 205 route de Narbonne, F-31077 Toulouse, France, Université de Toulouse; UPS; IPBS; F-31077 Toulouse, France
⨯

Gram-Positive Bacterial Lipoglycans Based on a Glycosylated Diacylglycerol Lipid Anchor Are Microbe-Associated Molecular Patterns Recognized by TLR2

Landry Blanc,
Romain Castanier,
Arun K. Mishra,
Aurélie Ray,
Gurdyal S. Besra,
Iain Sutcliffe,
Alain Vercellone,
Jérôme Nigou

Published: November 21, 2013
https://doi.org/10.1371/journal.pone.0081593

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Toll-like receptors
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Lipids
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Pattern recognition receptors
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Mycobacteria
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Gram positive bacteria
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Lipoproteins
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