Is the Cerebellum the Optimal Reference Region for Intensity Normalization of Perfusion MR Studies in Early Alzheimer’s Disease?

María Lacalle-Aurioles; Yasser Alemán-Gómez; Juan Adán Guzmán-De-Villoria; Isabel Cruz-Orduña; Javier Olazarán; José María Mateos-Pérez; María Elena Martino; Manuel Desco

doi:10.1371/journal.pone.0081548

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Peer-reviewed

Research Article

Is the Cerebellum the Optimal Reference Region for Intensity Normalization of Perfusion MR Studies in Early Alzheimer’s Disease?

María Lacalle-Aurioles ,

* E-mail: mlacalle@hggm.es

Affiliations Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Leganés, Madrid, Spain, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain
⨯
Yasser Alemán-Gómez,

Affiliations Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain
⨯
Juan Adán Guzmán-De-Villoria,

Affiliation Servicio de Radiodiagnóstico. Hospital General Universitario Gregorio Marañón, Madrid, Spain
⨯
Isabel Cruz-Orduña,

Affiliation Servicio de Neurología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
⨯
Javier Olazarán,

Affiliation Servicio de Neurología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
⨯
José María Mateos-Pérez,

Affiliations Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain
⨯
María Elena Martino,

Affiliation Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain
⨯
Manuel Desco

Affiliations Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Leganés, Madrid, Spain, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain
⨯

Is the Cerebellum the Optimal Reference Region for Intensity Normalization of Perfusion MR Studies in Early Alzheimer’s Disease?

María Lacalle-Aurioles,
Yasser Alemán-Gómez,
Juan Adán Guzmán-De-Villoria,
Isabel Cruz-Orduña,
Javier Olazarán,
José María Mateos-Pérez,
María Elena Martino,
Manuel Desco

Published: December 27, 2013
https://doi.org/10.1371/journal.pone.0081548

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Alzheimer's disease
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Cerebellum
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Cognitive impairment
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Magnetic resonance imaging
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Cerebral blood flow assay
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Temporal lobe
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Central nervous system
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Parietal lobe
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