ReliefSeq: A Gene-Wise Adaptive-K Nearest-Neighbor Feature Selection Tool for Finding Gene-Gene Interactions and Main Effects in mRNA-Seq Gene Expression Data

Brett A. McKinney; Bill C. White; Diane E. Grill; Peter W. Li; Richard B. Kennedy; Gregory A. Poland; Ann L. Oberg

doi:10.1371/journal.pone.0081527

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Peer-reviewed

Research Article

ReliefSeq: A Gene-Wise Adaptive-K Nearest-Neighbor Feature Selection Tool for Finding Gene-Gene Interactions and Main Effects in mRNA-Seq Gene Expression Data

Brett A. McKinney ,

* E-mail: brett.mckinney@gmail.com

Affiliations Tandy School of Computer Science, Department of Mathematics, University of Tulsa, Tulsa, Oklahoma, United States of America, Laureate Institute for Brain Research, Tulsa, Oklahoma, United States of America
⨯
Bill C. White,

Affiliation Tandy School of Computer Science, Department of Mathematics, University of Tulsa, Tulsa, Oklahoma, United States of America
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Diane E. Grill,

Affiliations Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America, Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, Minnesota, United States of America
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Peter W. Li,

Affiliations Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America, Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Richard B. Kennedy,

Affiliations Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America, Program in Translational Immunovirology and Biodefense, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Gregory A. Poland,

Affiliations Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America, Program in Translational Immunovirology and Biodefense, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Ann L. Oberg

Affiliations Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America, Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, Minnesota, United States of America
⨯

ReliefSeq: A Gene-Wise Adaptive-K Nearest-Neighbor Feature Selection Tool for Finding Gene-Gene Interactions and Main Effects in mRNA-Seq Gene Expression Data

Brett A. McKinney,
Bill C. White,
Diane E. Grill,
Peter W. Li,
Richard B. Kennedy,
Gregory A. Poland,
Ann L. Oberg

Published: December 10, 2013
https://doi.org/10.1371/journal.pone.0081527

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