Genetic Variation in DROSHA 3’UTR Regulated by hsa-miR-27b Is Associated with Bladder Cancer Risk

Lin Yuan; Haiyan Chu; Meilin Wang; Xiaojian Gu; Danni Shi; Lan Ma; Dongyan Zhong; Mulong Du; Pu Li; Na Tong; Guangbo Fu; Chao Qin; Changjun Yin; Zhengdong Zhang

doi:10.1371/journal.pone.0081524

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Open Access

Peer-reviewed

Research Article

Genetic Variation in DROSHA 3’UTR Regulated by hsa-miR-27b Is Associated with Bladder Cancer Risk

Lin Yuan ,

Contributed equally to this work with: Lin Yuan, Haiyan Chu, Meilin Wang

Affiliations Department of Urology, Jiangsu Province Hospital of TCM, Nanjing, China, State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China
⨯
Haiyan Chu ,

Contributed equally to this work with: Lin Yuan, Haiyan Chu, Meilin Wang

Affiliations State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China, Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China, Department of Genetic Toxicology, the Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China
⨯
Meilin Wang ,

Contributed equally to this work with: Lin Yuan, Haiyan Chu, Meilin Wang

Affiliations State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China, Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China, Department of Genetic Toxicology, the Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China
⨯
Xiaojian Gu,

Affiliation Department of Urology, Jiangsu Province Hospital of TCM, Nanjing, China
⨯
Danni Shi,

Affiliation Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China
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Lan Ma,

Affiliation Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China
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Dongyan Zhong,

Affiliation Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China
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Mulong Du,

Affiliation Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China
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Pu Li,

Affiliation Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China
⨯
Na Tong,

Affiliation Department of Genetic Toxicology, the Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China
⨯
Guangbo Fu,

Affiliation Department of Urology, the Huai-An First Affiliated Hospital of Nanjing Medical University, Huai-An, China
⨯
Chao Qin,

Affiliation Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China
⨯
Changjun Yin,

Affiliation Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China
⨯
Zhengdong Zhang

* E-mail: drzdzhang@gmail.com

Affiliations State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China, Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China, Department of Genetic Toxicology, the Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China
⨯

Genetic Variation in DROSHA 3’UTR Regulated by hsa-miR-27b Is Associated with Bladder Cancer Risk

Lin Yuan,
Haiyan Chu,
Meilin Wang,
Xiaojian Gu,
Danni Shi,
Lan Ma,
Dongyan Zhong,
Mulong Du,
Pu Li,
Na Tong

Published: November 28, 2013
https://doi.org/10.1371/journal.pone.0081524

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Bladder cancer
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3' UTR
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Cancer risk factors
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MicroRNAs
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Single nucleotide polymorphisms
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Gene expression
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Luciferase
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Variant genotypes
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