Functional Characterization of a Novel Frameshift Mutation in the C-terminus of the Nav1.5 Channel Underlying a Brugada Syndrome with Variable Expression in a Spanish Family

• Pablo Dolz-Gaitón ,

  Contributed equally to this work with: Pablo Dolz-Gaitón, Mercedes Núñez

  Affiliations Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain, Instituto de Investigación Sanitaria Gregorio Marañón, School of Medicine, Universidad Complutense, Madrid, Spain

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• Mercedes Núñez ,

  Contributed equally to this work with: Pablo Dolz-Gaitón, Mercedes Núñez

  Affiliations Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain, Instituto de Investigación Sanitaria Gregorio Marañón, School of Medicine, Universidad Complutense, Madrid, Spain

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• Lucía Núñez,

  Affiliation Complejo Hospitalario Universitario de A Coruña and Instituto de Ciencias de la Salud, Universidad de A Coruña, A Coruña, Spain

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• Adriana Barana,

  Affiliations Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain, Instituto de Investigación Sanitaria Hospital Clínico San Carlos, School of Medicine, Universidad Complutense, Madrid, Spain

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• Irene Amorós,

  Affiliations Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain, Instituto de Investigación Sanitaria Gregorio Marañón, School of Medicine, Universidad Complutense, Madrid, Spain

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• Marcos Matamoros,

  Affiliations Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain, Instituto de Investigación Sanitaria Gregorio Marañón, School of Medicine, Universidad Complutense, Madrid, Spain

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• Marta Pérez-Hernández,

  Affiliations Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain, Instituto de Investigación Sanitaria Hospital Clínico San Carlos, School of Medicine, Universidad Complutense, Madrid, Spain

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• Marta González de la Fuente,

  Affiliations Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain, Instituto de Investigación Sanitaria Hospital Clínico San Carlos, School of Medicine, Universidad Complutense, Madrid, Spain

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• Miguel Álvarez-López,

  Affiliation Arrhytmias Unit, Cardiology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain

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• Rosa Macías-Ruiz,

  Affiliation Arrhytmias Unit, Cardiology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain

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• Luis Tercedor-Sánchez,

  Affiliation Arrhytmias Unit, Cardiology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain

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• Juan Jiménez-Jáimez,

  Affiliation Arrhytmias Unit, Cardiology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain

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• Eva Delpón ,

  * E-mail: edelpon@med.ucm.es

  Affiliations Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain, Instituto de Investigación Sanitaria Gregorio Marañón, School of Medicine, Universidad Complutense, Madrid, Spain

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• Ricardo Caballero,

  Affiliations Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain, Instituto de Investigación Sanitaria Gregorio Marañón, School of Medicine, Universidad Complutense, Madrid, Spain

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• Juan Tamargo

  Affiliations Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain, Instituto de Investigación Sanitaria Hospital Clínico San Carlos, School of Medicine, Universidad Complutense, Madrid, Spain

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