The P2Y6 Receptor Mediates Clostridium difficile Toxin-Induced CXCL8/IL-8 Production and Intestinal Epithelial Barrier Dysfunction

Ashleigh Hansen; Laurie Alston; Sarah E. Tulk; L. Patrick Schenck; Michael E. Grassie; Basmah F. Alhassan; Arun Teja Veermalla; Samir Al-Bashir; Fernand-Pierre Gendron; Christophe Altier; Justin A. MacDonald; Paul L. Beck; Simon A. Hirota

doi:10.1371/journal.pone.0081491

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Open Access

Peer-reviewed

Research Article

The P2Y₆ Receptor Mediates Clostridium difficile Toxin-Induced CXCL8/IL-8 Production and Intestinal Epithelial Barrier Dysfunction

Ashleigh Hansen,

Affiliations Department of Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada, Department of Microbiology, Immunology & Infectious Disease, University of Calgary, Calgary, Alberta, Canada
⨯
Laurie Alston,

Affiliations Department of Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada, Department of Microbiology, Immunology & Infectious Disease, University of Calgary, Calgary, Alberta, Canada
⨯
Sarah E. Tulk,

Affiliation Department of Medicine, University of Calgary, Calgary, Alberta, Canada
⨯
L. Patrick Schenck,

Affiliations Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Department of Medicine, University of Calgary, Calgary, Alberta, Canada
⨯
Michael E. Grassie,

Affiliation Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada
⨯
Basmah F. Alhassan,

Affiliations Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Department of Medicine, University of Calgary, Calgary, Alberta, Canada
⨯
Arun Teja Veermalla,

Affiliation Department of Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada
⨯
Samir Al-Bashir,

Affiliation Department of Pathology and Laboratory Medicine, Jordan University of Science and Technology, Irbid, Jordan
⨯
Fernand-Pierre Gendron,

Affiliation Department of Anatomy & Cell Biology, University of Sherbrooke, Sherbrooke, Quebec, Canada
⨯
Christophe Altier,

Affiliation Department of Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada
⨯
Justin A. MacDonald,

Affiliation Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada
⨯
Paul L. Beck,

Affiliation Department of Medicine, University of Calgary, Calgary, Alberta, Canada
⨯
Simon A. Hirota

* E-mail: simon.hirota@ucalgary.ca

Affiliations Department of Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada, Department of Microbiology, Immunology & Infectious Disease, University of Calgary, Calgary, Alberta, Canada
⨯

The P2Y₆ Receptor Mediates Clostridium difficile Toxin-Induced CXCL8/IL-8 Production and Intestinal Epithelial Barrier Dysfunction

Ashleigh Hansen,
Laurie Alston,
Sarah E. Tulk,
L. Patrick Schenck,
Michael E. Grassie,
Basmah F. Alhassan,
Arun Teja Veermalla,
Samir Al-Bashir,
Fernand-Pierre Gendron,
Christophe Altier

Published: November 22, 2013
https://doi.org/10.1371/journal.pone.0081491

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