Inhibition of Elongation Factor-2 Kinase Augments the Antitumor Activity of Temozolomide against Glioma

Xiao-yuan Liu; Li Zhang; JianPing Wu; Lei Zhou; Yi-Jie Ren; Wei-Qiong Yang; Zi-Jun Ming; Bo Chen; Jianrong Wang; Yi Zhang; Jin-Ming Yang

doi:10.1371/journal.pone.0081345

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Open Access

Peer-reviewed

Research Article

Inhibition of Elongation Factor-2 Kinase Augments the Antitumor Activity of Temozolomide against Glioma

Xiao-yuan Liu ,

Contributed equally to this work with: Xiao-yuan Liu, Li Zhang

Current address: Department of Pharmaceutical Affairs, Wuxi No. 4 People’s Hospital, Wuxi, Jiangsu, China

Affiliation Department of Pharmacology, College of Pharmaceutical Sciences, Cyrus Tang Hematology Center, Affiliated Changshu Hospital, Soochow University, Suzhou, Jiangsu, China
⨯
Li Zhang ,

Contributed equally to this work with: Xiao-yuan Liu, Li Zhang

Affiliation Department of Pharmacology, College of Pharmaceutical Sciences, Cyrus Tang Hematology Center, Affiliated Changshu Hospital, Soochow University, Suzhou, Jiangsu, China
⨯
JianPing Wu,

Affiliation Department of Pharmacology, College of Pharmaceutical Sciences, Cyrus Tang Hematology Center, Affiliated Changshu Hospital, Soochow University, Suzhou, Jiangsu, China
⨯
Lei Zhou,

Affiliation Department of Pharmacology, College of Pharmaceutical Sciences, Cyrus Tang Hematology Center, Affiliated Changshu Hospital, Soochow University, Suzhou, Jiangsu, China
⨯
Yi-Jie Ren,

Affiliation Department of Pharmacology, College of Pharmaceutical Sciences, Cyrus Tang Hematology Center, Affiliated Changshu Hospital, Soochow University, Suzhou, Jiangsu, China
⨯
Wei-Qiong Yang,

Affiliation Department of Pharmacology, College of Pharmaceutical Sciences, Cyrus Tang Hematology Center, Affiliated Changshu Hospital, Soochow University, Suzhou, Jiangsu, China
⨯
Zi-Jun Ming,

Affiliation Department of Pharmacology, College of Pharmaceutical Sciences, Cyrus Tang Hematology Center, Affiliated Changshu Hospital, Soochow University, Suzhou, Jiangsu, China
⨯
Bo Chen,

Affiliation Department of Pharmacology, College of Pharmaceutical Sciences, Cyrus Tang Hematology Center, Affiliated Changshu Hospital, Soochow University, Suzhou, Jiangsu, China
⨯
Jianrong Wang,

Affiliation Department of Pharmacology, College of Pharmaceutical Sciences, Cyrus Tang Hematology Center, Affiliated Changshu Hospital, Soochow University, Suzhou, Jiangsu, China
⨯
Yi Zhang ,

* E-mail: juy16@psu.edu (JMY); zhangyi@suda.edu.cn (YZ)

Affiliation Department of Pharmacology, College of Pharmaceutical Sciences, Cyrus Tang Hematology Center, Affiliated Changshu Hospital, Soochow University, Suzhou, Jiangsu, China
⨯
Jin-Ming Yang

* E-mail: juy16@psu.edu (JMY); zhangyi@suda.edu.cn (YZ)

Affiliations Department of Pharmacology, College of Pharmaceutical Sciences, Cyrus Tang Hematology Center, Affiliated Changshu Hospital, Soochow University, Suzhou, Jiangsu, China, Department of Pharmacology and The Penn State Hershey Cancer Institute, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America
⨯

Inhibition of Elongation Factor-2 Kinase Augments the Antitumor Activity of Temozolomide against Glioma

Xiao-yuan Liu,
Li Zhang,
JianPing Wu,
Lei Zhou,
Yi-Jie Ren,
Wei-Qiong Yang,
Zi-Jun Ming,
Bo Chen,
Jianrong Wang,
Yi Zhang

Published: November 26, 2013
https://doi.org/10.1371/journal.pone.0081345

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