A Multi-Antigenic Adenoviral-Vectored Vaccine Improves BCG-Induced Protection of Goats against Pulmonary Tuberculosis Infection and Prevents Disease Progression

Bernat Pérez de Val; Enric Vidal; Bernardo Villarreal-Ramos; Sarah C. Gilbert; Anna Andaluz; Xavier Moll; Maite Martín; Miquel Nofrarías; Helen McShane; H. Martin Vordermeier; Mariano Domingo

doi:10.1371/journal.pone.0081317

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Open Access

Peer-reviewed

Research Article

A Multi-Antigenic Adenoviral-Vectored Vaccine Improves BCG-Induced Protection of Goats against Pulmonary Tuberculosis Infection and Prevents Disease Progression

Bernat Pérez de Val ,

* E-mail: bernat.perez@cresa.uab.cat

Affiliation Centre de Recerca en Sanitat Animal, Universitat autonoma de Barcelona–Investigación y tecnología Agroalimentarias, Campus de la Universitat Autònoma de Barcelona, Bellaterra, Catalonia, Spain
⨯
Enric Vidal,

Affiliation Centre de Recerca en Sanitat Animal, Universitat autonoma de Barcelona–Investigación y tecnología Agroalimentarias, Campus de la Universitat Autònoma de Barcelona, Bellaterra, Catalonia, Spain
⨯
Bernardo Villarreal-Ramos,

Affiliation TB Research Group, Animal Health and Veterinary Laboratories Agency-Weybridge, New Haw, Addlestone, Surrey, United Kingdom
⨯
Sarah C. Gilbert,

Affiliation The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, United Kingdom
⨯
Anna Andaluz,

Affiliation Departament de Medicina i Cirugia Animals, Universitat Autònoma de Barcelona, Bellaterra, Catalonia, Spain
⨯
Xavier Moll,

Affiliation Departament de Medicina i Cirugia Animals, Universitat Autònoma de Barcelona, Bellaterra, Catalonia, Spain
⨯
Maite Martín,

Affiliation Centre de Recerca en Sanitat Animal, Universitat autonoma de Barcelona–Investigación y tecnología Agroalimentarias, Campus de la Universitat Autònoma de Barcelona, Bellaterra, Catalonia, Spain
⨯
Miquel Nofrarías,

Affiliation Centre de Recerca en Sanitat Animal, Universitat autonoma de Barcelona–Investigación y tecnología Agroalimentarias, Campus de la Universitat Autònoma de Barcelona, Bellaterra, Catalonia, Spain
⨯
Helen McShane,

Affiliation The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, United Kingdom
⨯
H. Martin Vordermeier,

Affiliation TB Research Group, Animal Health and Veterinary Laboratories Agency-Weybridge, New Haw, Addlestone, Surrey, United Kingdom
⨯
Mariano Domingo

Affiliations Centre de Recerca en Sanitat Animal, Universitat autonoma de Barcelona–Investigación y tecnología Agroalimentarias, Campus de la Universitat Autònoma de Barcelona, Bellaterra, Catalonia, Spain, Departament de Sanitat i Anatomia Animals, Universitat Autònoma de Barcelona, Bellaterra, Catalonia, Spain
⨯

A Multi-Antigenic Adenoviral-Vectored Vaccine Improves BCG-Induced Protection of Goats against Pulmonary Tuberculosis Infection and Prevents Disease Progression

Bernat Pérez de Val,
Enric Vidal,
Bernardo Villarreal-Ramos,
Sarah C. Gilbert,
Anna Andaluz,
Xavier Moll,
Maite Martín,
Miquel Nofrarías,
Helen McShane,
H. Martin Vordermeier

Published: November 21, 2013
https://doi.org/10.1371/journal.pone.0081317

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Goats
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Vaccination and immunization
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