A Missense Mutation in CRYBB2 Leads to Progressive Congenital Membranous Cataract by Impacting the Solubility and Function of βB2-Crystallin

Weirong Chen; Xiaoyun Chen; Zhengmao Hu; Haotian Lin; Fengqi Zhou; Lixia Luo; Xinyu Zhang; Xiaojian Zhong; Ye Yang; Changrui Wu; Zhuoling Lin; Shaobi Ye; Yizhi Liu; for the study group of CCPMOH

doi:10.1371/journal.pone.0081290

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Open Access

Peer-reviewed

Research Article

A Missense Mutation in CRYBB2 Leads to Progressive Congenital Membranous Cataract by Impacting the Solubility and Function of βB2-Crystallin

Weirong Chen ,

Contributed equally to this work with: Weirong Chen, Xiaoyun Chen, Zhengmao Hu

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of China
⨯
Xiaoyun Chen ,

Contributed equally to this work with: Weirong Chen, Xiaoyun Chen, Zhengmao Hu

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of China
⨯
Zhengmao Hu ,

Contributed equally to this work with: Weirong Chen, Xiaoyun Chen, Zhengmao Hu

Affiliation State Key Laboratory of Medical Genetics, Xiangya Medical College, Central South University, Changsha, People's Republic of China
⨯
Haotian Lin,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of China
⨯
Fengqi Zhou,

Affiliation Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China
⨯
Lixia Luo,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of China
⨯
Xinyu Zhang,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of China
⨯
Xiaojian Zhong,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of China
⨯
Ye Yang,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of China
⨯
Changrui Wu,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of China
⨯
Zhuoling Lin,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of China
⨯
Shaobi Ye,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of China
⨯
Yizhi Liu ,

* E-mail: yizhi_liu@aliyun.com

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of China
⨯
for the study group of CCPMOH

¶Membership of the CCPMOH is provided in the Acknowledgments.
⨯

A Missense Mutation in CRYBB2 Leads to Progressive Congenital Membranous Cataract by Impacting the Solubility and Function of βB2-Crystallin

Weirong Chen,
Xiaoyun Chen,
Zhengmao Hu,
Haotian Lin,
Fengqi Zhou,
Lixia Luo,
Xinyu Zhang,
Xiaojian Zhong,
Ye Yang,
Changrui Wu

Published: November 28, 2013
https://doi.org/10.1371/journal.pone.0081290

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Restriction fragment length polymorphism analysis
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