A Mathematical Model of the Enhanced Permeability and Retention Effect for Liposome Transport in Solid Tumors

Shawn Stapleton; Michael Milosevic; Christine Allen; Jinzi Zheng; Michael Dunne; Ivan Yeung; David A. Jaffray

doi:10.1371/journal.pone.0081157

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Peer-reviewed

Research Article

A Mathematical Model of the Enhanced Permeability and Retention Effect for Liposome Transport in Solid Tumors

Shawn Stapleton ,

* E-mail: shawn.stapleton@rmp.uhn.on.ca

Affiliations Department of Medical Biophysics, University of Toronto, Ontario, Canada, STTARR Innovation Centre, Princess Margaret Cancer Centre, Toronto, Ontario, Canada
⨯
Michael Milosevic,

Affiliations STTARR Innovation Centre, Princess Margaret Cancer Centre, Toronto, Ontario, Canada, Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada, Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
⨯
Christine Allen,

Affiliation Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
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Jinzi Zheng,

Affiliations STTARR Innovation Centre, Princess Margaret Cancer Centre, Toronto, Ontario, Canada, Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada
⨯
Michael Dunne,

Affiliations STTARR Innovation Centre, Princess Margaret Cancer Centre, Toronto, Ontario, Canada, Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada
⨯
Ivan Yeung,

Affiliations STTARR Innovation Centre, Princess Margaret Cancer Centre, Toronto, Ontario, Canada, Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada, Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
⨯
David A. Jaffray

Affiliations Department of Medical Biophysics, University of Toronto, Ontario, Canada, STTARR Innovation Centre, Princess Margaret Cancer Centre, Toronto, Ontario, Canada, Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada, Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada, Techna Institute, University Health Network, Toronto, Ontario, Canada
⨯

A Mathematical Model of the Enhanced Permeability and Retention Effect for Liposome Transport in Solid Tumors

Shawn Stapleton,
Michael Milosevic,
Christine Allen,
Jinzi Zheng,
Michael Dunne,
Ivan Yeung,
David A. Jaffray

Published: December 2, 2013
https://doi.org/10.1371/journal.pone.0081157

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Cancers and neoplasms
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Liposomes
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Malignant tumors
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