Telomere-Binding Protein TPP1 Modulates Telomere Homeostasis and Confers Radioresistance to Human Colorectal Cancer Cells

Lei Yang; Wenbo Wang; Liu Hu; Xiaoxi Yang; Juan Zhong; Zheng Li; Hui Yang; Han Lei; Haijun Yu; ZhengKai Liao; Fuxiang Zhou; Conghua Xie; Yunfeng Zhou

doi:10.1371/journal.pone.0081034

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Open Access

Peer-reviewed

Research Article

Telomere-Binding Protein TPP1 Modulates Telomere Homeostasis and Confers Radioresistance to Human Colorectal Cancer Cells

Lei Yang ,

Contributed equally to this work with: Lei Yang, Wenbo Wang

Affiliation Hubei Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan, China
⨯
Wenbo Wang ,

Contributed equally to this work with: Lei Yang, Wenbo Wang

Affiliation Hubei Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan, China
⨯
Liu Hu,

Affiliation Hubei Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan, China
⨯
Xiaoxi Yang,

Affiliation Hubei Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan, China
⨯
Juan Zhong,

Affiliation Department of Oncology, the Fifth Hospital of Wuhan, Wuhan, China
⨯
Zheng Li,

Affiliation Hubei Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan, China
⨯
Hui Yang,

Affiliation Hubei Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan, China
⨯
Han Lei,

Affiliations Hubei Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan, China, Department of Radiation Oncology & Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, China
⨯
Haijun Yu,

Affiliations Hubei Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan, China, Department of Radiation Oncology & Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, China
⨯
ZhengKai Liao,

Affiliations Hubei Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan, China, Department of Radiation Oncology & Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, China
⨯
Fuxiang Zhou,

Affiliations Hubei Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan, China, Department of Radiation Oncology & Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, China
⨯
Conghua Xie,

Affiliations Hubei Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan, China, Department of Radiation Oncology & Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, China
⨯
Yunfeng Zhou

* E-mail: yfzhouwhu@163.com

Affiliations Hubei Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan, China, Department of Radiation Oncology & Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, China
⨯

Telomere-Binding Protein TPP1 Modulates Telomere Homeostasis and Confers Radioresistance to Human Colorectal Cancer Cells

Lei Yang,
Wenbo Wang,
Liu Hu,
Xiaoxi Yang,
Juan Zhong,
Zheng Li,
Hui Yang,
Han Lei,
Haijun Yu,
ZhengKai Liao

Published: November 19, 2013
https://doi.org/10.1371/journal.pone.0081034

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