Chemoresistance to Concanamycin A1 in Human Oral Squamous Cell Carcinoma Is Attenuated by an HDAC Inhibitor Partly via Suppression of Bcl-2 Expression

Tamotsu Kiyoshima; Hisato Yoshida; Hiroko Wada; Kengo Nagata; Hiroaki Fujiwara; Makiko Kihara; Kana Hasegawa; Hirotaka Someya; Hidetaka Sakai

doi:10.1371/journal.pone.0080998

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Peer-reviewed

Research Article

Chemoresistance to Concanamycin A1 in Human Oral Squamous Cell Carcinoma Is Attenuated by an HDAC Inhibitor Partly via Suppression of Bcl-2 Expression

Tamotsu Kiyoshima ,

* E-mail: kiyo@dent.kyushu-u.ac.jp

Affiliation Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
⨯
Hisato Yoshida,

Affiliation Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
⨯
Hiroko Wada,

Affiliation Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
⨯
Kengo Nagata,

Affiliation Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
⨯
Hiroaki Fujiwara,

Affiliation Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
⨯
Makiko Kihara,

Affiliations Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan, Department of Orthodontics, Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
⨯
Kana Hasegawa,

Affiliations Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan, Department of Endodontology and Operative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
⨯
Hirotaka Someya,

Affiliations Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan, Department of Removable Prosthodontics, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
⨯
Hidetaka Sakai

Affiliation Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
⨯

Chemoresistance to Concanamycin A1 in Human Oral Squamous Cell Carcinoma Is Attenuated by an HDAC Inhibitor Partly via Suppression of Bcl-2 Expression

Tamotsu Kiyoshima,
Hisato Yoshida,
Hiroko Wada,
Kengo Nagata,
Hiroaki Fujiwara,
Makiko Kihara,
Kana Hasegawa,
Hirotaka Someya,
Hidetaka Sakai

Published: November 20, 2013
https://doi.org/10.1371/journal.pone.0080998

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