Co-Transplantation of GDNF-Overexpressing Neural Stem Cells and Fetal Dopaminergic Neurons Mitigates Motor Symptoms in a Rat Model of Parkinson’s Disease

Xingli Deng; Yuanxin Liang; Hua Lu; Zhiyong Yang; Ru’en Liu; Jinkun Wang; Xiaobin Song; Jiang Long; Yu Li; Deqiang Lei; Zhongtang Feng

doi:10.1371/journal.pone.0080880

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Open Access

Peer-reviewed

Research Article

Co-Transplantation of GDNF-Overexpressing Neural Stem Cells and Fetal Dopaminergic Neurons Mitigates Motor Symptoms in a Rat Model of Parkinson’s Disease

Xingli Deng ,

Contributed equally to this work with: Xingli Deng, Yuanxin Liang

Affiliation Department of Neurosurgery, 1st Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
⨯
Yuanxin Liang ,

Contributed equally to this work with: Xingli Deng, Yuanxin Liang

Affiliation Cancer Center, Albert Einstein College of Medicine, New York, United States of America
⨯
Hua Lu,

Affiliation Department of Neurosurgery, 1st Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
⨯
Zhiyong Yang,

Affiliation Department of Neurosurgery, 1st Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
⨯
Ru’en Liu ,

* E-mail: liuruen@gmail.com

Affiliation Department of Neurosurgery; China-Japan Friendship Hospital, Beijing, China
⨯
Jinkun Wang,

Affiliation Department of Neurosurgery, 1st Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
⨯
Xiaobin Song,

Affiliation Department of Neurosurgery, 1st Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
⨯
Jiang Long,

Affiliation Department of Neurosurgery, 1st Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
⨯
Yu Li,

Affiliation Department of Neurosurgery, 1st Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
⨯
Deqiang Lei,

Affiliation Department of Neurosurgery, Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Zhongtang Feng

Affiliation Department of Neurosurgery, 1st Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
⨯

Co-Transplantation of GDNF-Overexpressing Neural Stem Cells and Fetal Dopaminergic Neurons Mitigates Motor Symptoms in a Rat Model of Parkinson’s Disease

Xingli Deng,
Yuanxin Liang,
Hua Lu,
Zhiyong Yang,
Ru’en Liu,
Jinkun Wang,
Xiaobin Song,
Jiang Long,
Yu Li,
Deqiang Lei

Published: December 3, 2013
https://doi.org/10.1371/journal.pone.0080880

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